HCSGD entry for CDC25C

1. General information

Official gene symbolCDC25C
Entrez ID995
Gene full namecell division cycle 25C
Other gene symbolsCDC25 PPP1R60
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000079Regulation of cyclin-dependent protein serine/threonine kinase activityTASbiological_process
GO:0000086G2/M transition of mitotic cell cycleIGI TASbiological_process
GO:0000278Mitotic cell cycleTASbiological_process
GO:0004725Protein tyrosine phosphatase activityIEA NASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005622IntracellularIEAcellular_component
GO:0005634NucleusIDA IEAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005829CytosolTAScellular_component
GO:0006260DNA replicationTASbiological_process
GO:0007067MitosisIEAbiological_process
GO:0007088Regulation of mitosisTASbiological_process
GO:0007283SpermatogenesisIEAbiological_process
GO:0008283Cell proliferationTASbiological_process
GO:0016032Viral processIEAbiological_process
GO:0019901Protein kinase bindingIPImolecular_function
GO:0035335Peptidyl-tyrosine dephosphorylationNASbiological_process
GO:0048471Perinuclear region of cytoplasmIEAcellular_component
GO:0050699WW domain bindingIPImolecular_function
GO:0051726Regulation of cell cycleTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.97114928380.00203401470.99999024730.0859176000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0634595492
GSE13712_SHEARDown-0.0516875716
GSE13712_STATICDown-0.5516766093
GSE19018Up0.1184828609
GSE19899_A1Down-0.3211892593
GSE19899_A2Down-1.9425683242
PubMed_21979375_A1Down-0.8681162363
PubMed_21979375_A2Down-1.9424823995
GSE35957Down-1.0497541364
GSE36640Down-2.5068547746
GSE54402Down-0.4094630358
GSE9593Down-0.3558970120
GSE43922Down-1.2370593757
GSE24585Up0.4901715006
GSE37065Down-0.0859437562
GSE28863_A1Down-0.1960652365
GSE28863_A2Up0.4514493991
GSE28863_A3Down-0.4094566777
GSE28863_A4Down-0.0228967708
GSE48662Down-0.9082952634

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-34a-5pMIMAT0000255MIRT000751MicroarrayFunctional MTI (Weak)19461653
hsa-miR-221-3pMIMAT0000278MIRT046939CLASHFunctional MTI (Weak)23622248
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    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-125b-5pMIMAT0000423NAhsa-miR-125b21935352
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26476078Growth suppression was mediated by G1 blockade involving increased p21 expression and suppressed cyclin B1, CDK1, and CDC25C
21113463Cell transfection with anti-E6 and anti-E7 short interfering RNA moderately reduced the expression of mRNA for CDC25C, GRB2, GTSE1, and PLK1 genes and induced expression of CDKN1A (p21(CIP)) gene mRNA
21047732Expression profiles of time series after OTX2 induction in MED8A showed early upregulation of cell cycle genes related to the G(2)-M phase, such as AURKA, CDC25C, and CCNG2
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