HCSGD entry for CDC25B
1. General information
| Official gene symbol | CDC25B |
|---|---|
| Entrez ID | 994 |
| Gene full name | cell division cycle 25B |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000086 | G2/M transition of mitotic cell cycle | TAS | biological_process |
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0000922 | Spindle pole | IDA | cellular_component |
| GO:0001556 | Oocyte maturation | IEA | biological_process |
| GO:0004725 | Protein tyrosine phosphatase activity | IEA TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005622 | Intracellular | IEA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005813 | Centrosome | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006468 | Protein phosphorylation | IDA | biological_process |
| GO:0007067 | Mitosis | IEA | biological_process |
| GO:0007144 | Female meiosis I | IEA | biological_process |
| GO:0008284 | Positive regulation of cell proliferation | TAS | biological_process |
| GO:0019901 | Protein kinase binding | IPI | molecular_function |
| GO:0032467 | Positive regulation of cytokinesis | IMP | biological_process |
| GO:0035335 | Peptidyl-tyrosine dephosphorylation | TAS | biological_process |
| GO:0045860 | Positive regulation of protein kinase activity | IEA | biological_process |
| GO:0045931 | Positive regulation of mitotic cell cycle | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9761971430 | 0.0004894609 | 0.9999902473 | 0.0411066038 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1519330504 |
| GSE13712_SHEAR | Down | -1.0784087369 |
| GSE13712_STATIC | Down | -0.7261611645 |
| GSE19018 | Up | 0.3063763240 |
| GSE19899_A1 | Down | -1.2429988304 |
| GSE19899_A2 | Down | -2.7093810994 |
| PubMed_21979375_A1 | Down | -1.2580639132 |
| PubMed_21979375_A2 | Down | -1.9174753141 |
| GSE35957 | Down | -2.6283376670 |
| GSE36640 | Down | -1.7487489133 |
| GSE54402 | Down | -0.7308740818 |
| GSE9593 | Down | -0.5626244452 |
| GSE43922 | Down | -0.6114639556 |
| GSE24585 | Up | 0.0694324614 |
| GSE37065 | Up | 0.0555681383 |
| GSE28863_A1 | Down | -0.2367087543 |
| GSE28863_A2 | Up | 0.0873371576 |
| GSE28863_A3 | Up | 0.2681326504 |
| GSE28863_A4 | Up | 0.0341248199 |
| GSE48662 | Down | -0.7164782074 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Double Oxidized Cysteine | DB01769 | EXPT01040 |
| Cysteinesulfonic Acid | DB03661 | EXPT02415 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-7-5p | MIMAT0000252 | MIRT025904 | Microarray | Functional MTI (Weak) | 19073608 |
| hsa-miR-148a-3p | MIMAT0000243 | MIRT026017 | Reporter assay;Western blot;Other | Functional MTI | 21709669 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT030153 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-744-5p | MIMAT0004945 | MIRT037634 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-296-3p | MIMAT0004679 | MIRT038444 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7a-5p | MIMAT0000062 | MIRT052555 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-204-5p | MIMAT0000265 | NA | hsa-miR-204 | 20369013 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
