HCSGD entry for MFN2
1. General information
| Official gene symbol | MFN2 |
|---|---|
| Entrez ID | 9927 |
| Gene full name | mitofusin 2 |
| Other gene symbols | CMT2A CMT2A2 CPRP1 HSG MARF |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001825 | Blastocyst formation | IEA | biological_process |
| GO:0003924 | GTPase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005525 | GTP binding | IEA | molecular_function |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0005741 | Mitochondrial outer membrane | IEA TAS | cellular_component |
| GO:0005829 | Cytosol | ISS | cellular_component |
| GO:0006626 | Protein targeting to mitochondrion | IDA | biological_process |
| GO:0007006 | Mitochondrial membrane organization | IDA | biological_process |
| GO:0007050 | Cell cycle arrest | ISS | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0008053 | Mitochondrial fusion | IEA IMP NAS | biological_process |
| GO:0008219 | Cell death | IEA | biological_process |
| GO:0015630 | Microtubule cytoskeleton | IEA | cellular_component |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0031306 | Intrinsic component of mitochondrial outer membrane | ISS | cellular_component |
| GO:0031625 | Ubiquitin protein ligase binding | IPI | molecular_function |
| GO:0046580 | Negative regulation of Ras protein signal transduction | IDA | biological_process |
| GO:0048593 | Camera-type eye morphogenesis | IEA | biological_process |
| GO:0048662 | Negative regulation of smooth muscle cell proliferation | IEA ISS | biological_process |
| GO:0051646 | Mitochondrion localization | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4250622659 | 0.4862780821 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0586196868 |
| GSE13712_SHEAR | Up | 0.2497493391 |
| GSE13712_STATIC | Up | 0.1797258028 |
| GSE19018 | Down | -0.0739867224 |
| GSE19899_A1 | Down | -0.0409025790 |
| GSE19899_A2 | Up | 0.0734779563 |
| PubMed_21979375_A1 | Up | 0.1621693505 |
| PubMed_21979375_A2 | Up | 0.0753043733 |
| GSE35957 | Up | 0.1697143371 |
| GSE36640 | Down | -0.0159913871 |
| GSE54402 | Up | 0.1867846834 |
| GSE9593 | Up | 0.0864853458 |
| GSE43922 | Down | -0.0500959182 |
| GSE24585 | Down | -0.0529116341 |
| GSE37065 | Down | -0.1445351414 |
| GSE28863_A1 | Up | 0.1085393407 |
| GSE28863_A2 | Up | 0.6446503055 |
| GSE28863_A3 | Down | -0.7783073664 |
| GSE28863_A4 | Down | -0.2525079360 |
| GSE48662 | Up | 0.1394001120 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT023877 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031906 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041312 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT041972 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-99b-5p | MIMAT0000689 | MIRT044188 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT046976 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT047398 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT048771 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049714 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-1260b | MIMAT0015041 | MIRT052698 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-3619-5p | MIMAT0017999 | MIRT052861 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
