HCSGD entry for KLHL21
1. General information
| Official gene symbol | KLHL21 |
|---|---|
| Entrez ID | 9903 |
| Gene full name | kelch-like family member 21 |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004842 | Ubiquitin-protein ligase activity | IDA | molecular_function |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005827 | Polar microtubule | IDA | cellular_component |
| GO:0007067 | Mitosis | IEA | biological_process |
| GO:0016567 | Protein ubiquitination | IDA | biological_process |
| GO:0031463 | Cul3-RING ubiquitin ligase complex | IDA | cellular_component |
| GO:0032465 | Regulation of cytokinesis | IMP | biological_process |
| GO:0035853 | Chromosome passenger complex localization to spindle midzone | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0009054595 | 0.9825488887 | 0.0824657439 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.6338578767 |
| GSE13712_SHEAR | Up | 0.9816042743 |
| GSE13712_STATIC | Up | 0.6110119656 |
| GSE19018 | Down | -0.7580790336 |
| GSE19899_A1 | Up | 0.7279544035 |
| GSE19899_A2 | Up | 1.5231295066 |
| PubMed_21979375_A1 | Up | 1.2355427564 |
| PubMed_21979375_A2 | Up | 1.7802238567 |
| GSE35957 | Up | 0.4595950470 |
| GSE36640 | Up | 0.8206502056 |
| GSE54402 | Up | 0.3470752020 |
| GSE9593 | Up | 0.9252826754 |
| GSE43922 | Up | 0.4449159787 |
| GSE24585 | Up | 0.2223739256 |
| GSE37065 | Up | 0.2660878735 |
| GSE28863_A1 | Up | 0.0634372416 |
| GSE28863_A2 | Up | 0.9981035570 |
| GSE28863_A3 | Down | -0.1186784215 |
| GSE28863_A4 | Down | -0.2894742561 |
| GSE48662 | Up | 0.2175305746 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-130b-3p | MIMAT0000691 | MIRT020304 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029862 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-19b-3p | MIMAT0000074 | MIRT031234 | Sequencing | Functional MTI (Weak) | 20371350 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
