HCSGD entry for FIG4
1. General information
| Official gene symbol | FIG4 |
|---|---|
| Entrez ID | 9896 |
| Gene full name | FIG4 homolog, SAC1 lipid phosphatase domain containing (S. cerevisiae) |
| Other gene symbols | ALS11 CMT4J KIAA0274 SAC3 dJ249I4.1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000139 | Golgi membrane | TAS | cellular_component |
| GO:0004438 | Phosphatidylinositol-3-phosphatase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0006644 | Phospholipid metabolic process | TAS | biological_process |
| GO:0006661 | Phosphatidylinositol biosynthetic process | TAS | biological_process |
| GO:0007033 | Vacuole organization | IEA | biological_process |
| GO:0007626 | Locomotory behavior | IEA | biological_process |
| GO:0008219 | Cell death | IEA | biological_process |
| GO:0010008 | Endosome membrane | IDA | cellular_component |
| GO:0010976 | Positive regulation of neuron projection development | IEA | biological_process |
| GO:0016311 | Dephosphorylation | TAS | biological_process |
| GO:0031642 | Negative regulation of myelination | IEA | biological_process |
| GO:0031901 | Early endosome membrane | TAS | cellular_component |
| GO:0031902 | Late endosome membrane | TAS | cellular_component |
| GO:0032288 | Myelin assembly | IEA | biological_process |
| GO:0034593 | Phosphatidylinositol bisphosphate phosphatase activity | IEA | molecular_function |
| GO:0036092 | Phosphatidylinositol-3-phosphate biosynthetic process | TAS | biological_process |
| GO:0042578 | Phosphoric ester hydrolase activity | IEA | molecular_function |
| GO:0043473 | Pigmentation | IEA | biological_process |
| GO:0043812 | Phosphatidylinositol-4-phosphate phosphatase activity | IEA | molecular_function |
| GO:0043813 | Phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity | TAS | molecular_function |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046488 | Phosphatidylinositol metabolic process | IEA | biological_process |
| GO:0048666 | Neuron development | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4929567874 | 0.0913857262 | 0.9999902473 | 0.5750331580 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0244110255 |
| GSE13712_SHEAR | Down | -0.5259927674 |
| GSE13712_STATIC | Down | -0.1084687373 |
| GSE19018 | Up | 0.5993874280 |
| GSE19899_A1 | Down | -0.5934477682 |
| GSE19899_A2 | Up | 0.3402425587 |
| PubMed_21979375_A1 | Down | -0.0799188357 |
| PubMed_21979375_A2 | Up | 0.5195893787 |
| GSE35957 | Up | 0.0464782458 |
| GSE36640 | Up | 0.1490132327 |
| GSE54402 | Down | -0.6650988855 |
| GSE9593 | Up | 0.2433838757 |
| GSE43922 | Down | -0.2543650778 |
| GSE24585 | Up | 0.3407099149 |
| GSE37065 | Up | 0.0833825419 |
| GSE28863_A1 | Down | -0.2332279623 |
| GSE28863_A2 | Up | 0.1776998115 |
| GSE28863_A3 | Down | -0.8186378147 |
| GSE28863_A4 | Down | -0.1956987348 |
| GSE48662 | Down | -0.0658105773 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT019027 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-1 | MIMAT0000416 | MIRT024087 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT030214 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 19686285 | Here, we found that the level of germinal center-associated nuclear protein (GANP), a mammalian homologue of yeast Sac3, was markedly decreased in MGs with a poor prognosis; and thus we explored the effect of its decrease on cell-cycle progression of MG cell lines |
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