HCSGD entry for NUAK1
1. General information
| Official gene symbol | NUAK1 |
|---|---|
| Entrez ID | 9891 |
| Gene full name | NUAK family, SNF1-like kinase, 1 |
| Other gene symbols | ARK5 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002039 | P53 binding | IPI | molecular_function |
| GO:0004674 | Protein serine/threonine kinase activity | IDA IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0006974 | Cellular response to DNA damage stimulus | IEA | biological_process |
| GO:0007155 | Cell adhesion | IEA | biological_process |
| GO:0016772 | Transferase activity, transferring phosphorus-containing groups | IEA | molecular_function |
| GO:0030155 | Regulation of cell adhesion | IDA | biological_process |
| GO:0035507 | Regulation of myosin-light-chain-phosphatase activity | IDA | biological_process |
| GO:0042127 | Regulation of cell proliferation | TAS | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:2000772 | Regulation of cellular senescence | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0076934729 | 0.0486798602 | 0.2280695163 | 0.4128161571 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -2.1303454331 |
| GSE13712_SHEAR | Down | -1.5416344877 |
| GSE13712_STATIC | Up | 0.0646834627 |
| GSE19018 | Down | -0.2255747449 |
| GSE19899_A1 | Up | 1.0386343089 |
| GSE19899_A2 | Up | 1.3656925447 |
| PubMed_21979375_A1 | Up | 1.1770175590 |
| PubMed_21979375_A2 | Up | 1.7191316012 |
| GSE35957 | Up | 0.5764567022 |
| GSE36640 | Up | 0.8584563696 |
| GSE54402 | Up | 0.9067169902 |
| GSE9593 | Up | 0.5395368746 |
| GSE43922 | Up | 0.5054232375 |
| GSE24585 | Up | 0.2526609962 |
| GSE37065 | Down | -0.4087273713 |
| GSE28863_A1 | Down | -0.4896120581 |
| GSE28863_A2 | Down | -0.6096733456 |
| GSE28863_A3 | Down | -0.5751636024 |
| GSE28863_A4 | Down | -0.0446623093 |
| GSE48662 | Up | 0.5409881972 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-186-5p | MIMAT0000456 | MIRT021136 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-1 | MIMAT0000416 | MIRT023849 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT028149 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-26a-5p | MIMAT0000082 | MIRT050078 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22418434 | Muscle-specific knock-out of NUAK family SNF1-like kinase 1 (NUAK1) prevents high fat diet-induced glucose intolerance |
| 22418434 | NUAK1 is a member of the AMP-activated protein kinase-related kinase family |
| 22418434 | Recent studies have shown that NUAK1 is involved in cellular senescence and motility in epithelial cells and fibroblasts |
| 22418434 | However, the physiological roles of NUAK1 are poorly understood because of embryonic lethality in NUAK1 null mice |
| 22418434 | The purpose of this study was to elucidate the roles of NUAK1 in adult tissues |
| 22418434 | We determined the tissue distribution of NUAK1 and generated muscle-specific NUAK1 knock-out (MNUAK1KO) mice |
| 22418434 | Nuak1 mRNA was preferentially expressed in highly oxidative tissues such as brain, heart, and soleus muscle |
| 22418434 | These observations suggest that a physiological role of NUAK1 is to suppress glucose uptake through negative regulation of insulin signaling in oxidative muscle |
| 21317932 | A new role of NUAK1: directly phosphorylating p53 and regulating cell proliferation |
| 21317932 | Apart from evidence to suggest that NUAK1 participates in induction of tumor survival, invasion and p53-independent cellular senescence, its detailed biological functions remain unclear |
| 21317932 | Here we showed that in the presence of wild-type LKB1, NUAK1 directly interacts with and phosphorylates p53 in vitro and in vivo |
| 21317932 | The phosphorylation of p53 induced by LKB1 required the kinase activity of NUAK1 and phosphorylation of NUAK1 at Thr211 by LKB1 was essential for its kinase activity, which leads to the conclusion that LKB1 activates NUAK1 and regulates phosphorylation of p53 through the NUAK1 kinase, at least partially |
| 21317932 | Under the regulation of LKB1, NUAK1 interacts with p53 in the nucleus and binds to the p53-responsive element of p21/WAF1 promoter |
| 21317932 | These findings have highlighted a novel role for NUAK1 in LKB1-related signaling pathways; NUAK1 can regulate cell proliferation and exert tumor suppression through direct interaction with p53 |
| 19927127 | Regulation of ploidy and senescence by the AMPK-related kinase NUAK1 |
| 19927127 | We show that downregulation of the AMPK-related protein kinase 5 (ARK5 or NUAK1) results in extension of the cellular replicative lifespan |
| 19927127 | Interestingly, the levels of NUAK1 are upregulated during senescence whereas its ectopic expression triggers a premature senescence |
| 19927127 | Cells that constitutively express NUAK1 suffer gross aneuploidies and show diminished expression of the genomic stability regulator LATS1, whereas depletion of NUAK1 with shRNA exerts opposite effects |
| 19927127 | Interestingly, a dominant-negative form of LATS1 phenocopies NUAK1 effects |
| 19927127 | Moreover, we show that NUAK1 phosphorylates LATS1 at S464 and this has a role in controlling its stability |
| 19927127 | In summary, our work highlights a novel role for NUAK1 in the control of cellular senescence and cellular ploidy |
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