HCSGD entry for GAB2
1. General information
| Official gene symbol | GAB2 |
|---|---|
| Entrez ID | 9846 |
| Gene full name | GRB2-associated binding protein 2 |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005068 | Transmembrane receptor protein tyrosine kinase adaptor activity | IDA | molecular_function |
| GO:0005070 | SH3/SH2 adaptor activity | RCA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005547 | Phosphatidylinositol-3,4,5-trisphosphate binding | ISS | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0007169 | Transmembrane receptor protein tyrosine kinase signaling pathway | IDA | biological_process |
| GO:0008284 | Positive regulation of cell proliferation | IDA | biological_process |
| GO:0009967 | Positive regulation of signal transduction | IDA RCA | biological_process |
| GO:0030316 | Osteoclast differentiation | IMP | biological_process |
| GO:0038095 | Fc-epsilon receptor signaling pathway | TAS | biological_process |
| GO:0043306 | Positive regulation of mast cell degranulation | ISS | biological_process |
| GO:0043325 | Phosphatidylinositol-3,4-bisphosphate binding | ISS | molecular_function |
| GO:0045087 | Innate immune response | TAS | biological_process |
| GO:0048015 | Phosphatidylinositol-mediated signaling | ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1406659663 | 0.7204646898 | 0.7529561814 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0546522198 |
| GSE13712_SHEAR | Down | -0.3313277584 |
| GSE13712_STATIC | Down | -0.2149856633 |
| GSE19018 | Down | -0.0321020609 |
| GSE19899_A1 | Down | -0.0499690840 |
| GSE19899_A2 | Down | -0.3215075710 |
| PubMed_21979375_A1 | Down | -0.0763857453 |
| PubMed_21979375_A2 | Down | -0.0825061814 |
| GSE35957 | Up | 0.8356692989 |
| GSE36640 | Up | 0.2610723029 |
| GSE54402 | Up | 0.2455424934 |
| GSE9593 | Up | 1.0116247129 |
| GSE43922 | Down | -0.0006726630 |
| GSE24585 | Up | 0.0842561938 |
| GSE37065 | Up | 0.2940665380 |
| GSE28863_A1 | Down | -0.3290835592 |
| GSE28863_A2 | Up | 0.1123857718 |
| GSE28863_A3 | Up | 0.5881717790 |
| GSE28863_A4 | Up | 0.0304130324 |
| GSE48662 | Up | 0.0004176971 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017199 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024466 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026255 | Microarray | Functional MTI (Weak) | 19074876 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
