HCSGD entry for ZEB2
1. General information
| Official gene symbol | ZEB2 |
|---|---|
| Entrez ID | 9839 |
| Gene full name | zinc finger E-box binding homeobox 2 |
| Other gene symbols | HSPC082 SIP-1 SIP1 SMADIP1 ZFHX1B |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001755 | Neural crest cell migration | IEA | biological_process |
| GO:0001756 | Somitogenesis | IEA | biological_process |
| GO:0001843 | Neural tube closure | IEA | biological_process |
| GO:0003676 | Nucleic acid binding | IEA | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0007399 | Nervous system development | NAS | biological_process |
| GO:0019208 | Phosphatase regulator activity | NAS | molecular_function |
| GO:0021766 | Hippocampus development | IEA | biological_process |
| GO:0021846 | Cell proliferation in forebrain | IEA | biological_process |
| GO:0030177 | Positive regulation of Wnt signaling pathway | IEA | biological_process |
| GO:0043507 | Positive regulation of JUN kinase activity | IEA | biological_process |
| GO:0043565 | Sequence-specific DNA binding | IEA | molecular_function |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0070412 | R-SMAD binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4059636146 | 0.4895382470 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1136710174 |
| GSE13712_SHEAR | Up | 0.1203113611 |
| GSE13712_STATIC | Down | -0.2547013825 |
| GSE19018 | Down | -0.0565699117 |
| GSE19899_A1 | Up | 0.0593785955 |
| GSE19899_A2 | Up | 0.1414792406 |
| PubMed_21979375_A1 | Down | -0.1002521379 |
| PubMed_21979375_A2 | Down | -0.3818711554 |
| GSE35957 | Down | -0.1005613784 |
| GSE36640 | Down | -0.0212873705 |
| GSE54402 | Up | 0.1571411520 |
| GSE9593 | Down | -0.0101025023 |
| GSE43922 | Down | -0.2442434364 |
| GSE24585 | Down | -0.2264616818 |
| GSE37065 | Up | 0.4461840882 |
| GSE28863_A1 | Up | 0.5393999599 |
| GSE28863_A2 | Up | 0.4635526096 |
| GSE28863_A3 | Up | 0.1141054799 |
| GSE28863_A4 | Down | -0.0655305541 |
| GSE48662 | Up | 0.3208467646 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-429 | MIMAT0001536 | MIRT000048 | Luciferase reporter assay//qRT-PCR | Functional MTI | 18411277 |
| hsa-miR-429 | MIMAT0001536 | MIRT000048 | Luciferase reporter assay | Functional MTI | 19854497 |
| hsa-miR-429 | MIMAT0001536 | MIRT000048 | Luciferase reporter assay | Functional MTI | 18829540 |
| hsa-miR-429 | MIMAT0001536 | MIRT000048 | intrarenal expression | Functional MTI (Weak) | 19910931 |
| hsa-miR-141-3p | MIMAT0000432 | MIRT000316 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 19830559 |
| hsa-miR-141-3p | MIMAT0000432 | MIRT000316 | Luciferase reporter assay//qRT-PCR | Non-Functional MTI | 18411277 |
| hsa-miR-141-3p | MIMAT0000432 | MIRT000316 | Luciferase reporter assay | Functional MTI | 19854497 |
| hsa-miR-200b-3p | MIMAT0000318 | MIRT000723 | Luciferase reporter assay//qRT-PCR | Functional MTI | 18411277 |
| hsa-miR-200b-3p | MIMAT0000318 | MIRT000723 | Luciferase reporter assay//Microarray//Western blot | Functional MTI | 18376396 |
| hsa-miR-200b-3p | MIMAT0000318 | MIRT000723 | Luciferase reporter assay | Functional MTI | 19839049 |
| hsa-miR-200b-3p | MIMAT0000318 | MIRT000723 | Luciferase reporter assay | Functional MTI | 18829540 |
| hsa-miR-200b-3p | MIMAT0000318 | MIRT000723 | Luciferase reporter assay//qRT-PCR | Functional MTI | 19854497 |
| hsa-miR-200b-3p | MIMAT0000318 | MIRT000723 | intrarenal expression | Functional MTI (Weak) | 19910931 |
| hsa-miR-200b-3p | MIMAT0000318 | MIRT000723 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 21049046 |
| hsa-miR-200b-3p | MIMAT0000318 | MIRT000723 | Luciferase reporter assay | Functional MTI | 22311119 |
| hsa-miR-200a-3p | MIMAT0000682 | MIRT001035 | Luciferase reporter assay//qRT-PCR | Functional MTI | 18411277 |
| hsa-miR-200a-3p | MIMAT0000682 | MIRT001035 | qRT-PCR//Western blot | Functional MTI | 19703993 |
| hsa-miR-200a-3p | MIMAT0000682 | MIRT001035 | qRT-PCR//Luciferase reporter assay//Western blot | Functional MTI | 18381893 |
| hsa-miR-200a-3p | MIMAT0000682 | MIRT001035 | Luciferase reporter assay//Microarray//Western blot | Functional MTI | 18376396 |
| hsa-miR-200a-3p | MIMAT0000682 | MIRT001035 | Luciferase reporter assay//qRT-PCR | Functional MTI | 19854497 |
| hsa-miR-200a-3p | MIMAT0000682 | MIRT001035 | Luciferase reporter assay | Functional MTI | 18829540 |
| hsa-miR-200a-3p | MIMAT0000682 | MIRT001035 | intrarenal expression | Functional MTI (Weak) | 19910931 |
| hsa-miR-200a-3p | MIMAT0000682 | MIRT001035 | Luciferase reporter assay//qRT-PCR//Western blot//Western blot;qRT-PCR | Functional MTI | 19931509 |
| hsa-miR-200a-3p | MIMAT0000682 | MIRT001035 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 21049046 |
| hsa-miR-200a-3p | MIMAT0000682 | MIRT001035 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 21529905 |
| hsa-miR-200c-3p | MIMAT0000617 | MIRT001036 | Luciferase reporter assay//qRT-PCR | Non-Functional MTI | 18411277 |
| hsa-miR-200c-3p | MIMAT0000617 | MIRT001036 | qRT-PCR//Luciferase reporter assay//Western blot | Functional MTI | 18381893 |
| hsa-miR-200c-3p | MIMAT0000617 | MIRT001036 | Luciferase reporter assay | Functional MTI | 19839049 |
| hsa-miR-200c-3p | MIMAT0000617 | MIRT001036 | Luciferase reporter assay | Functional MTI | 19854497 |
| hsa-miR-200c-3p | MIMAT0000617 | MIRT001036 | Immunoblot//Luciferase reporter assay//qRT-PCR | Functional MTI | 21294122 |
| hsa-miR-200c-3p | MIMAT0000617 | MIRT001036 | Luciferase reporter assay | Functional MTI | 20620960 |
| hsa-miR-200c-3p | MIMAT0000617 | MIRT001036 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 21049046 |
| hsa-miR-200c-3p | MIMAT0000617 | MIRT001036 | Luciferase reporter assay//Western blot | Functional MTI | 22569286 |
| hsa-miR-205-5p | MIMAT0000266 | MIRT003666 | Luciferase reporter assay//Microarray//Western blot | Functional MTI | 18376396 |
| hsa-miR-205-5p | MIMAT0000266 | MIRT003666 | immunoblot//qRT-PCR | Functional MTI (Weak) | 19244118 |
| hsa-miR-153-3p | MIMAT0000439 | MIRT007099 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 23188671 |
| hsa-miR-138-5p | MIMAT0000430 | MIRT021691 | Reporter assay;qRT-PCR | Functional MTI | 21770894 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT024209 | Reporter assay;Western blot;qRT-PCR | Functional MTI | 20516212 |
| hsa-miR-320a | MIMAT0000510 | MIRT044428 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-181a-5p | MIMAT0000256 | MIRT047309 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-200b-3p | MIMAT0000318 | NA | hsa-miR-200b | 18376396 | |||
| hsa-miR-200a-3p | MIMAT0000682 | NA | hsa-miR-200a | 18376396 | |||
| hsa-miR-205-5p | MIMAT0000266 | NA | hsa-miR-205 | 18376396 | |||
| hsa-miR-205-5p | MIMAT0000266 | NA | hsa-miR-205 | 19244118 | |||
| hsa-miR-200a-3p | MIMAT0000682 | NA | hsa-miR-200a | 20037478 | |||
| hsa-miR-200b-3p | MIMAT0000318 | NA | hsa-miR-200b | 20037478 | |||
| hsa-miR-141-3p | MIMAT0000432 | 1 | hsa-miR-141 | {Western blot} | {overexpression by miRNA precursor transfection} | 19830559 | |
| hsa-miR-141-3p | MIMAT0000432 | 2 | hsa-miR-141 | {Western blot} | {overexpression by miRNA precursor transfection} | 19830559 | |
| hsa-miR-708-5p | MIMAT0004926 | 1 | hsa-miR-708 | 21852381 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24853424 | In addition, we show that WIF1 functions as a positive regulator of miR-200c, leading to downregulation of BMI1, ZEB1 and ZEB2, with a consequent increase in downstream targets such as E-cadherin |
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