HCSGD entry for MELK
1. General information
| Official gene symbol | MELK |
|---|---|
| Entrez ID | 9833 |
| Gene full name | maternal embryonic leucine zipper kinase |
| Other gene symbols | HPK38 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000086 | G2/M transition of mitotic cell cycle | TAS | biological_process |
| GO:0004674 | Protein serine/threonine kinase activity | IDA | molecular_function |
| GO:0004715 | Non-membrane spanning protein tyrosine kinase activity | IDA | molecular_function |
| GO:0005509 | Calcium ion binding | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0005938 | Cell cortex | IDA | cellular_component |
| GO:0006915 | Apoptotic process | IDA | biological_process |
| GO:0008283 | Cell proliferation | IDA | biological_process |
| GO:0008289 | Lipid binding | IEA | molecular_function |
| GO:0008631 | Intrinsic apoptotic signaling pathway in response to oxidative stress | IEA | biological_process |
| GO:0018108 | Peptidyl-tyrosine phosphorylation | IDA | biological_process |
| GO:0030097 | Hemopoiesis | ISS | biological_process |
| GO:0043065 | Positive regulation of apoptotic process | ISS | biological_process |
| GO:0046777 | Protein autophosphorylation | IDA | biological_process |
| GO:0061351 | Neural precursor cell proliferation | ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9735058508 | 0.0000267505 | 0.9999902473 | 0.0091714286 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -1.5231473280 |
| GSE13712_SHEAR | Up | 0.3796055044 |
| GSE13712_STATIC | Down | -0.0505838877 |
| GSE19018 | Up | 0.0146389535 |
| GSE19899_A1 | Down | -3.1140507849 |
| GSE19899_A2 | Down | -3.0778277057 |
| PubMed_21979375_A1 | Down | -3.1628616853 |
| PubMed_21979375_A2 | Down | -4.8090665485 |
| GSE35957 | Down | -3.2864021538 |
| GSE36640 | Down | -3.6427418779 |
| GSE54402 | Down | -1.0625361767 |
| GSE9593 | Down | -0.6913545982 |
| GSE43922 | Down | -2.1252464640 |
| GSE24585 | Up | 0.1184875703 |
| GSE37065 | Down | -0.6767140353 |
| GSE28863_A1 | Down | -0.3115748378 |
| GSE28863_A2 | Up | 0.2972369036 |
| GSE28863_A3 | Down | -0.1268516986 |
| GSE28863_A4 | Up | 0.2219025115 |
| GSE48662 | Down | -1.7455797588 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016391 | Microarray | Functional MTI (Weak) | 20304954 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25772242 | We show that MOZ is required to maintain normal levels of histone 3 lysine 9 (H3K9) and H3K27 acetylation at the transcriptional start sites of at least four genes, Cdc6, Ezh2, E2f2 and Melk, and normal mRNA levels of these genes |
| 25772242 | Using chromatin immunoprecipitation, we show that MOZ occupies the Cdc6, Ezh2 and Melk loci, thereby providing a direct link between MOZ, H3K9 and H3K27 acetylation, and normal transcriptional levels at these loci |
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