HCSGD entry for ARHGEF11

1. General information

Official gene symbolARHGEF11
Entrez ID9826
Gene full nameRho guanine nucleotide exchange factor (GEF) 11
Other gene symbolsGTRAP48 PDZ-RHOGEF
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000910CytokinesisNASbiological_process
GO:0001558Regulation of cell growthNASbiological_process
GO:0001664G-protein coupled receptor bindingIDAmolecular_function
GO:0005089Rho guanyl-nucleotide exchange factor activityIEA TASmolecular_function
GO:0005096GTPase activator activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005622IntracellularICcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006928Cellular component movementNASbiological_process
GO:0006941Striated muscle contractionNASbiological_process
GO:0007186G-protein coupled receptor signaling pathwayIDA TASbiological_process
GO:0007264Small GTPase mediated signal transductionTASbiological_process
GO:0007266Rho protein signal transductionIDAbiological_process
GO:0007411Axon guidanceTASbiological_process
GO:0016020MembraneIEAcellular_component
GO:0030010Establishment of cell polarityNASbiological_process
GO:0030036Actin cytoskeleton organizationNASbiological_process
GO:0032318Regulation of Ras GTPase activityTASbiological_process
GO:0032319Regulation of Rho GTPase activityTASbiological_process
GO:0038032Termination of G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0043065Positive regulation of apoptotic processTASbiological_process
GO:0043087Regulation of GTPase activityTASbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDAbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0051056Regulation of small GTPase mediated signal transductionTASbiological_process
GO:0097190Apoptotic signaling pathwayTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.15729251550.91904076970.78745772161.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0108668555
GSE13712_SHEARUp0.0044725367
GSE13712_STATICUp0.1141404611
GSE19018Up0.0650956943
GSE19899_A1Up0.0071563575
GSE19899_A2Up0.1669083273
PubMed_21979375_A1Up0.0910343881
PubMed_21979375_A2Up0.0682540690
GSE35957Up0.0106863069
GSE36640Up0.3329555635
GSE54402Up0.0185256005
GSE9593Up0.4215863951
GSE43922Down-0.0134973839
GSE24585Up0.0958387201
GSE37065Up0.1340933729
GSE28863_A1Up0.5432526234
GSE28863_A2Up0.7649747943
GSE28863_A3Down-0.1204660279
GSE28863_A4Down-0.2200046313
GSE48662Up0.0590543010

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.