HCSGD entry for RB1CC1
1. General information
| Official gene symbol | RB1CC1 |
|---|---|
| Entrez ID | 9821 |
| Gene full name | RB1-inducible coiled-coil 1 |
| Other gene symbols | CC1 FIP200 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000045 | Autophagic vacuole assembly | IEA | biological_process |
| GO:0001889 | Liver development | IEA | biological_process |
| GO:0001934 | Positive regulation of protein phosphorylation | IEA | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005829 | Cytosol | IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0007049 | Cell cycle | IEA | biological_process |
| GO:0007254 | JNK cascade | IEA | biological_process |
| GO:0007507 | Heart development | IEA | biological_process |
| GO:0010506 | Regulation of autophagy | IEA ISS | biological_process |
| GO:0019901 | Protein kinase binding | IEA | molecular_function |
| GO:0034045 | Pre-autophagosomal structure membrane | IEA ISS | cellular_component |
| GO:0043066 | Negative regulation of apoptotic process | IEA | biological_process |
| GO:0045793 | Positive regulation of cell size | IEA | biological_process |
| GO:0070969 | ULK1-ATG13-FIP200 complex | IEA IPI | cellular_component |
| GO:2001237 | Negative regulation of extrinsic apoptotic signaling pathway | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0341816420 | 0.9469141978 | 0.4247283962 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2443273498 |
| GSE13712_SHEAR | Down | -0.0856750162 |
| GSE13712_STATIC | Down | -0.0031883555 |
| GSE19018 | Up | 0.5417875699 |
| GSE19899_A1 | Up | 0.5387359041 |
| GSE19899_A2 | Up | 0.3583834685 |
| PubMed_21979375_A1 | Up | 0.5147471566 |
| PubMed_21979375_A2 | Up | 0.4297409463 |
| GSE35957 | Up | 0.2812629350 |
| GSE36640 | Up | 0.1455908667 |
| GSE54402 | Up | 0.1836769895 |
| GSE9593 | Up | 0.1445261048 |
| GSE43922 | Up | 0.4041796536 |
| GSE24585 | Down | -0.1581696265 |
| GSE37065 | Down | -0.0454703336 |
| GSE28863_A1 | Up | 0.2804796989 |
| GSE28863_A2 | Up | 0.3000222920 |
| GSE28863_A3 | Down | -0.4849339757 |
| GSE28863_A4 | Up | 0.0747360624 |
| GSE48662 | Down | -0.3829085824 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-133b | MIMAT0000770 | MIRT007127 | Luciferase reporter assay | Functional MTI | 23451058 |
| hsa-miR-375 | MIMAT0000728 | MIRT020069 | Microarray | Functional MTI (Weak) | 20215506 |
| hsa-miR-98-5p | MIMAT0000096 | MIRT027791 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041413 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24732589 | Tumor-suppressive functions of 15-Lipoxygenase-2 and RB1CC1 in prostate cancer |
| 24732589 | RB1CC1 knockdown in PC3 cells enhances clonal growth in vitro and tumor growth in vivo |
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