HCSGD entry for RNF40
1. General information
| Official gene symbol | RNF40 |
|---|---|
| Entrez ID | 9810 |
| Gene full name | ring finger protein 40, E3 ubiquitin protein ligase |
| Other gene symbols | BRE1B RBP95 STARING |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000151 | Ubiquitin ligase complex | IDA | cellular_component |
| GO:0004842 | Ubiquitin-protein ligase activity | IDA IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0006511 | Ubiquitin-dependent protein catabolic process | IEA ISS | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0010390 | Histone monoubiquitination | IDA | biological_process |
| GO:0017075 | Syntaxin-1 binding | IEA | molecular_function |
| GO:0031625 | Ubiquitin protein ligase binding | IPI | molecular_function |
| GO:0032403 | Protein complex binding | IEA | molecular_function |
| GO:0033503 | HULC complex | IDA | cellular_component |
| GO:0033523 | Histone H2B ubiquitination | IDA | biological_process |
| GO:0042803 | Protein homodimerization activity | IPI | molecular_function |
| GO:0043005 | Neuron projection | IEA ISS | cellular_component |
| GO:0043234 | Protein complex | IEA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1762121652 | 0.8757606740 | 0.8241676262 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0730926857 |
| GSE13712_SHEAR | Up | 0.0606587568 |
| GSE13712_STATIC | Up | 0.1687066190 |
| GSE19018 | Down | -0.0456122252 |
| GSE19899_A1 | Down | -0.1138594826 |
| GSE19899_A2 | Up | 0.0900213780 |
| PubMed_21979375_A1 | Up | 1.1742714712 |
| PubMed_21979375_A2 | Up | 0.8124244487 |
| GSE35957 | Down | -0.3064774083 |
| GSE36640 | Up | 0.0486534169 |
| GSE54402 | Up | 0.1135600178 |
| GSE9593 | Down | -0.2670921252 |
| GSE43922 | Up | 0.3268999859 |
| GSE24585 | Down | -0.2917743481 |
| GSE37065 | Down | -0.0895922297 |
| GSE28863_A1 | Up | 0.2766053467 |
| GSE28863_A2 | Up | 0.2811323911 |
| GSE28863_A3 | Down | -0.0640534133 |
| GSE28863_A4 | Up | 0.0100816272 |
| GSE48662 | Up | 0.4384656792 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025228 | Proteomics | Functional MTI (Weak) | 21566225 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT032413 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-1229-3p | MIMAT0005584 | MIRT036354 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-769-5p | MIMAT0003886 | MIRT039167 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-331-3p | MIMAT0000760 | MIRT043403 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT045027 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049341 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
