HCSGD entry for MTSS1
1. General information
| Official gene symbol | MTSS1 |
|---|---|
| Entrez ID | 9788 |
| Gene full name | metastasis suppressor 1 |
| Other gene symbols | MIM MIMA MIMB |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001726 | Ruffle | NAS | cellular_component |
| GO:0003779 | Actin binding | IEA | molecular_function |
| GO:0003785 | Actin monomer binding | IDA | molecular_function |
| GO:0005102 | Receptor binding | IPI | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IEA TAS | cellular_component |
| GO:0006928 | Cellular component movement | NAS | biological_process |
| GO:0007155 | Cell adhesion | NAS | biological_process |
| GO:0007165 | Signal transduction | IEA | biological_process |
| GO:0007169 | Transmembrane receptor protein tyrosine kinase signaling pathway | TAS | biological_process |
| GO:0008093 | Cytoskeletal adaptor activity | IEA | molecular_function |
| GO:0015629 | Actin cytoskeleton | IDA | cellular_component |
| GO:0017124 | SH3 domain binding | IEA | molecular_function |
| GO:0030035 | Microspike assembly | NAS | biological_process |
| GO:0030036 | Actin cytoskeleton organization | IEA TAS | biological_process |
| GO:0030041 | Actin filament polymerization | IEA | biological_process |
| GO:0030139 | Endocytic vesicle | TAS | cellular_component |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
| GO:0046847 | Filopodium assembly | IEA | biological_process |
| GO:0050680 | Negative regulation of epithelial cell proliferation | ISS | biological_process |
| GO:0061333 | Renal tubule morphogenesis | ISS | biological_process |
| GO:0071498 | Cellular response to fluid shear stress | ISS | biological_process |
| GO:0072102 | Glomerulus morphogenesis | ISS | biological_process |
| GO:0072160 | Nephron tubule epithelial cell differentiation | ISS | biological_process |
| GO:2001013 | Epithelial cell proliferation involved in renal tubule morphogenesis | ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1557072566 | 0.3890522359 | 0.7838180532 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0952719453 |
| GSE13712_SHEAR | Up | 0.1772087609 |
| GSE13712_STATIC | Down | -0.4306344531 |
| GSE19018 | Up | 0.2504991641 |
| GSE19899_A1 | Down | -0.0552489963 |
| GSE19899_A2 | Up | 0.0360960649 |
| PubMed_21979375_A1 | Down | -0.1770273970 |
| PubMed_21979375_A2 | Down | -0.0913507043 |
| GSE35957 | Up | 0.7371410116 |
| GSE36640 | Up | 0.4798969578 |
| GSE54402 | Down | -0.2719891511 |
| GSE9593 | Up | 0.5831127700 |
| GSE43922 | Down | -0.7354746785 |
| GSE24585 | Down | -0.3379802658 |
| GSE37065 | Up | 0.3471213209 |
| GSE28863_A1 | Up | 0.1061142676 |
| GSE28863_A2 | Up | 0.2585803940 |
| GSE28863_A3 | Up | 0.2917538962 |
| GSE28863_A4 | Up | 0.0981146619 |
| GSE48662 | Down | -0.2004940355 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-182-5p | MIMAT0000259 | MIRT006300 | Luciferase reporter assay | Functional MTI | 22322863 |
| hsa-miR-182-5p | MIMAT0000259 | MIRT006300 | Luciferase reporter assay | Functional MTI | 23383207 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024949 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026400 | Microarray | Functional MTI (Weak) | 19074876 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
