HCSGD entry for EIF4A3
1. General information
| Official gene symbol | EIF4A3 |
|---|---|
| Entrez ID | 9775 |
| Gene full name | eukaryotic translation initiation factor 4A3 |
| Other gene symbols | DDX48 NMP265 NUK34 eIF4AIII |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000184 | Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | IMP TAS | biological_process |
| GO:0000288 | Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | TAS | biological_process |
| GO:0000289 | Nuclear-transcribed mRNA poly(A) tail shortening | TAS | biological_process |
| GO:0000398 | MRNA splicing, via spliceosome | IC | biological_process |
| GO:0003676 | Nucleic acid binding | IEA | molecular_function |
| GO:0003729 | MRNA binding | IDA | molecular_function |
| GO:0004004 | ATP-dependent RNA helicase activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IDA IEA | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006200 | ATP catabolic process | IDA | biological_process |
| GO:0006364 | RRNA processing | IEA | biological_process |
| GO:0008026 | ATP-dependent helicase activity | IEA | molecular_function |
| GO:0008143 | Poly(A) binding | IDA | molecular_function |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0016070 | RNA metabolic process | TAS | biological_process |
| GO:0016071 | MRNA metabolic process | TAS | biological_process |
| GO:0016607 | Nuclear speck | IEA | cellular_component |
| GO:0017148 | Negative regulation of translation | IDA | biological_process |
| GO:0019221 | Cytokine-mediated signaling pathway | TAS | biological_process |
| GO:0035145 | Exon-exon junction complex | IDA | cellular_component |
| GO:0045727 | Positive regulation of translation | IMP | biological_process |
| GO:0051028 | MRNA transport | IEA | biological_process |
| GO:0071013 | Catalytic step 2 spliceosome | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1498887124 | 0.1332162798 | 0.7745680864 | 0.7029642542 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1250331561 |
| GSE13712_SHEAR | Up | 0.3653774286 |
| GSE13712_STATIC | Up | 0.3833833182 |
| GSE19018 | Down | -1.2112497052 |
| GSE19899_A1 | Up | 0.0917298443 |
| GSE19899_A2 | Up | 0.1655474078 |
| PubMed_21979375_A1 | Up | 0.7490670925 |
| PubMed_21979375_A2 | Down | -0.0042412569 |
| GSE35957 | Down | -0.8558894579 |
| GSE36640 | Down | -0.7418691972 |
| GSE54402 | Up | 0.4399110892 |
| GSE9593 | Down | -0.4848196087 |
| GSE43922 | Up | 0.2536995004 |
| GSE24585 | Up | 0.3328731007 |
| GSE37065 | Down | -0.1027281190 |
| GSE28863_A1 | Up | 0.3611201574 |
| GSE28863_A2 | Up | 0.4275523618 |
| GSE28863_A3 | Down | -0.5257066777 |
| GSE28863_A4 | Up | 0.1747498535 |
| GSE48662 | Down | -0.6982604738 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-26b-5p | MIMAT0000083 | MIRT030151 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-877-3p | MIMAT0004950 | MIRT036955 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-18a-3p | MIMAT0002891 | MIRT040853 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-3p | MIMAT0000762 | MIRT042843 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-331-3p | MIMAT0000760 | MIRT043493 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-99b-5p | MIMAT0000689 | MIRT044207 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-183-5p | MIMAT0000261 | MIRT047149 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
