HCSGD entry for KIAA0101
1. General information
| Official gene symbol | KIAA0101 |
|---|---|
| Entrez ID | 9768 |
| Gene full name | KIAA0101 |
| Other gene symbols | NS5ATP9 OEATC OEATC-1 OEATC1 PAF PAF15 p15(PAF) p15/PAF p15PAF |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003682 | Chromatin binding | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0006260 | DNA replication | IDA | biological_process |
| GO:0006974 | Cellular response to DNA damage stimulus | IDA | biological_process |
| GO:0009411 | Response to UV | IDA | biological_process |
| GO:0019985 | Translesion synthesis | IMP | biological_process |
| GO:0048471 | Perinuclear region of cytoplasm | IDA | cellular_component |
| GO:0051297 | Centrosome organization | IMP | biological_process |
| GO:0051726 | Regulation of cell cycle | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9726024125 | 0.0000110748 | 0.9999902473 | 0.0069833333 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -2.0547331699 |
| GSE13712_SHEAR | Down | -0.1762361173 |
| GSE13712_STATIC | Down | -0.7770145719 |
| GSE19018 | Down | -0.0907739224 |
| GSE19899_A1 | Down | -2.3618030680 |
| GSE19899_A2 | Down | -3.4969026816 |
| PubMed_21979375_A1 | Down | -3.5581082093 |
| PubMed_21979375_A2 | Down | -4.4563586897 |
| GSE35957 | Down | -3.6311599038 |
| GSE36640 | Down | -3.9989466371 |
| GSE54402 | Down | -0.6874184879 |
| GSE9593 | Down | -1.7037008076 |
| GSE43922 | Down | -2.2655111689 |
| GSE24585 | Down | -0.0886366586 |
| GSE37065 | Down | -0.7128782212 |
| GSE28863_A1 | Down | -0.2468306158 |
| GSE28863_A2 | Up | 0.6398877324 |
| GSE28863_A3 | Down | -0.4493716589 |
| GSE28863_A4 | Up | 0.5661479811 |
| GSE48662 | Down | -2.5106335640 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016453 | Microarray | Functional MTI (Weak) | 20304954 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT022855 | Proteomics;Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-122-5p | MIMAT0000421 | MIRT023371 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-181a-5p | MIMAT0000256 | MIRT025163 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029795 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27116545 | A plasmid expressing KIAA0101 without its 3'-untranslated region (3'-UTR) was cotransfected with miR-183 to evaluate the role of KIAA0101 on the effects induced by miR-183 |
| 27116545 | Expression of KIAA0101 lacking the 3'-UTR region partially prevented the effects of miR-183 on cell proliferation and completely reversed the effects on UV-induced DNA damage |
| 27116545 | CONCLUSIONS: Our results suggest that the observed up-regulation of miR-183 after stress-induced senescence in HTM cells may contribute to reinforce cellular senescence by inhibiting cell cycle progression through multiple gene targets and limiting the DNA repair mechanisms through inhibition of KIAA0101 |
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