HCSGD entry for KMT2B

1. General information

Official gene symbolKMT2B
Entrez ID9757
Gene full namelysine (K)-specific methyltransferase 2B
Other gene symbolsHRX2 MLL1B MLL2 MLL4 TRX2 WBP7
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001541Ovarian follicle developmentIEAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityNASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0009994Oocyte differentiationIEAbiological_process
GO:0016458Gene silencingIEAbiological_process
GO:0030728OvulationIEAbiological_process
GO:0035097Histone methyltransferase complexIDAcellular_component
GO:0042800Histone methyltransferase activity (H3-K4 specific)IDAmolecular_function
GO:0048096Chromatin-mediated maintenance of transcriptionNASbiological_process
GO:0051568Histone H3-K4 methylationIMPbiological_process
GO:0051569Regulation of histone H3-K4 methylationIEAbiological_process
GO:0080182Histone H3-K4 trimethylationIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.52594836060.85989446070.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0510015164
GSE13712_SHEARDown-0.1344812607
GSE13712_STATICUp0.0672491546
GSE19018Down-0.1737771367
GSE19899_A1Up0.0074276671
GSE19899_A2Up0.0906869974
PubMed_21979375_A1Down-0.1285323995
PubMed_21979375_A2Up0.2292331573
GSE35957Down-0.3349930078
GSE36640Down-0.0331603163
GSE54402Up0.0360267510
GSE9593Down-0.0055449497
GSE43922Up0.0748388801
GSE24585Down-0.1393143015
GSE37065Up0.1418041688
GSE28863_A1Up0.2078057076
GSE28863_A2Up0.1503023540
GSE28863_A3Up0.3215585818
GSE28863_A4Up0.0549722334
GSE48662Up0.0685574591

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.