HCSGD entry for SLK
1. General information
| Official gene symbol | SLK |
|---|---|
| Entrez ID | 9748 |
| Gene full name | STE20-like kinase |
| Other gene symbols | LOSK STK2 bA16H23.1 se20-9 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004674 | Protein serine/threonine kinase activity | IDA | molecular_function |
| GO:0004702 | Receptor signaling protein serine/threonine kinase activity | IBA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0006915 | Apoptotic process | IEA | biological_process |
| GO:0007165 | Signal transduction | IBA | biological_process |
| GO:0023014 | Signal transduction by phosphorylation | IBA | biological_process |
| GO:0035556 | Intracellular signal transduction | IBA | biological_process |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
| GO:0042803 | Protein homodimerization activity | IDA | molecular_function |
| GO:0046777 | Protein autophosphorylation | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1069036435 | 0.2122360359 | 0.6794300266 | 0.8891667038 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2959447743 |
| GSE13712_SHEAR | Down | -0.1248473532 |
| GSE13712_STATIC | Up | 0.2270808112 |
| GSE19018 | Down | -0.2328997627 |
| GSE19899_A1 | Up | 0.2585311268 |
| GSE19899_A2 | Down | -0.3739826946 |
| PubMed_21979375_A1 | Down | -0.3305386883 |
| PubMed_21979375_A2 | Down | -0.5291272064 |
| GSE35957 | Up | 0.1427322292 |
| GSE36640 | Up | 0.1045473862 |
| GSE54402 | Down | -0.1176148200 |
| GSE9593 | Up | 0.0328350114 |
| GSE43922 | Down | -0.0224219596 |
| GSE24585 | Down | -0.3140172374 |
| GSE37065 | Up | 0.1856725128 |
| GSE28863_A1 | Up | 1.5340910510 |
| GSE28863_A2 | Up | 1.3965270889 |
| GSE28863_A3 | Down | -0.0539780726 |
| GSE28863_A4 | Up | 0.3392969299 |
| GSE48662 | Down | -0.5862382967 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE | DB07664 | - |
| [4-({4-[(5-CYCLOPROPYL-1H-PYRAZOL-3-YL)AMINO]QUINAZOLIN-2-YL}IMINO)CYCLOHEXA-2,5-DIEN-1-YL]ACETONITRILE | DB07853 | - |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-21-5p | MIMAT0000076 | MIRT031072 | Microarray | Functional MTI (Weak) | 20371350 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT031072 | Microarray | Functional MTI (Weak) | 18591254 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040336 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT042026 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7c-5p | MIMAT0000064 | MIRT051774 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
