HCSGD entry for DOCK4
1. General information
| Official gene symbol | DOCK4 |
|---|---|
| Entrez ID | 9732 |
| Gene full name | dedicator of cytokinesis 4 |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0060326 | Cell chemotaxis | IMP | biological_process |
| GO:0005829 | Cytosol | IDA | cellular_component |
| GO:0012505 | Endomembrane system | IEA | cellular_component |
| GO:0005085 | Guanyl-nucleotide exchange factor activity | IEA | molecular_function |
| GO:0016020 | Membrane | IDA | cellular_component |
| GO:0030165 | PDZ domain binding | IPI | molecular_function |
| GO:0043085 | Positive regulation of catalytic activity | IDA | biological_process |
| GO:0043547 | Positive regulation of GTPase activity | IDA | biological_process |
| GO:0032855 | Positive regulation of Rac GTPase activity | IDA | biological_process |
| GO:0032320 | Positive regulation of Ras GTPase activity | IDA | biological_process |
| GO:0032321 | Positive regulation of Rho GTPase activity | IDA | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0030675 | Rac GTPase activator activity | IDA | molecular_function |
| GO:0048365 | Rac GTPase binding | IDA | molecular_function |
| GO:0030971 | Receptor tyrosine kinase binding | IPI | molecular_function |
| GO:0050790 | Regulation of catalytic activity | IDA | biological_process |
| GO:0017124 | SH3 domain binding | IEA | molecular_function |
| GO:0007264 | Small GTPase mediated signal transduction | IEA | biological_process |
| GO:0032420 | Stereocilium | ISS | cellular_component |
| GO:0032421 | Stereocilium bundle | ISS | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0039625736 | 0.9772777250 | 0.1689315534 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.4598520234 |
| GSE13712_SHEAR | Up | 0.1812256347 |
| GSE13712_STATIC | Down | -0.0503750064 |
| GSE19018 | Down | -0.0441736302 |
| GSE19899_A1 | Up | 0.8551586566 |
| GSE19899_A2 | Up | 0.4760829376 |
| PubMed_21979375_A1 | Up | 1.5266607790 |
| PubMed_21979375_A2 | Up | 0.7920533328 |
| GSE35957 | Down | -0.1926647716 |
| GSE36640 | Up | 0.4660645920 |
| GSE54402 | Up | 1.1609936782 |
| GSE9593 | Up | 0.0029000955 |
| GSE43922 | Up | 1.6935929147 |
| GSE24585 | Down | -0.1767153986 |
| GSE37065 | Up | 0.3541524675 |
| GSE28863_A1 | Up | 0.3172188473 |
| GSE28863_A2 | Down | -0.2913718265 |
| GSE28863_A3 | Up | 0.3026884227 |
| GSE28863_A4 | Up | 0.2473187776 |
| GSE48662 | Up | 0.0397065091 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-21-5p | MIMAT0000076 | MIRT006313 | Immunoblot//Luciferase reporter assay//qRT-PCR | Functional MTI | 22158624 |
| hsa-miR-98-5p | MIMAT0000096 | MIRT027576 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT005411 | Microarray | Functional MTI (Weak) | 19193853 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
