HCSGD entry for ESPL1
1. General information
| Official gene symbol | ESPL1 |
|---|---|
| Entrez ID | 9700 |
| Gene full name | extra spindle pole bodies homolog 1 (S. cerevisiae) |
| Other gene symbols | ESP1 SEPA |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000070 | Mitotic sister chromatid segregation | IEA IMP | biological_process |
| GO:0000212 | Meiotic spindle organization | IEA | biological_process |
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0000910 | Cytokinesis | NAS | biological_process |
| GO:0003824 | Catalytic activity | NAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005813 | Centrosome | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006508 | Proteolysis | IEA | biological_process |
| GO:0006915 | Apoptotic process | TAS | biological_process |
| GO:0008233 | Peptidase activity | IEA | molecular_function |
| GO:0008234 | Cysteine-type peptidase activity | NAS TAS | molecular_function |
| GO:0040001 | Establishment of mitotic spindle localization | NAS | biological_process |
| GO:0045143 | Homologous chromosome segregation | IEA | biological_process |
| GO:0045842 | Positive regulation of mitotic metaphase/anaphase transition | NAS | biological_process |
| GO:0045875 | Negative regulation of sister chromatid cohesion | NAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2530639071 | 0.0887351696 | 0.9427406338 | 0.5649882680 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0553896148 |
| GSE13712_SHEAR | Up | 1.3796892103 |
| GSE13712_STATIC | Up | 0.0477492715 |
| GSE19018 | Up | 0.0262710793 |
| GSE19899_A1 | Down | -0.3133595978 |
| GSE19899_A2 | Down | -0.2795874494 |
| PubMed_21979375_A1 | Up | 1.1756085028 |
| PubMed_21979375_A2 | Up | 0.1254251368 |
| GSE35957 | Down | -1.4708973682 |
| GSE36640 | Down | -1.4313436901 |
| GSE54402 | Down | -0.0657787341 |
| GSE9593 | Down | -0.3908643952 |
| GSE43922 | Up | 0.0389943773 |
| GSE24585 | Down | -0.1380514791 |
| GSE37065 | Down | -0.2441615039 |
| GSE28863_A1 | Down | -0.0968790703 |
| GSE28863_A2 | Up | 0.4710663183 |
| GSE28863_A3 | Up | 0.0513023190 |
| GSE28863_A4 | Up | 0.1801812294 |
| GSE48662 | Down | -0.3197737967 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016597 | Microarray | Functional MTI (Weak) | 20304954 |
| hsa-miR-196a-5p | MIMAT0000226 | MIRT026060 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-let-7d-5p | MIMAT0000065 | MIRT032164 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039621 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-149-5p | MIMAT0000450 | MIRT045591 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-210-3p | MIMAT0000267 | MIRT047005 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-10a-5p | MIMAT0000253 | MIRT047734 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
