HCSGD entry for EDEM1
1. General information
| Official gene symbol | EDEM1 |
|---|---|
| Entrez ID | 9695 |
| Gene full name | ER degradation enhancer, mannosidase alpha-like 1 |
| Other gene symbols | EDEM |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004571 | Mannosyl-oligosaccharide 1,2-alpha-mannosidase activity | IDA IEA | molecular_function |
| GO:0005509 | Calcium ion binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005789 | Endoplasmic reticulum membrane | TAS | cellular_component |
| GO:0006457 | Protein folding | TAS | biological_process |
| GO:0006987 | Activation of signaling protein activity involved in unfolded protein response | TAS | biological_process |
| GO:0016020 | Membrane | IEA | cellular_component |
| GO:0018279 | Protein N-linked glycosylation via asparagine | TAS | biological_process |
| GO:0030176 | Integral component of endoplasmic reticulum membrane | ISS | cellular_component |
| GO:0030433 | ER-associated ubiquitin-dependent protein catabolic process | ISS | biological_process |
| GO:0030968 | Endoplasmic reticulum unfolded protein response | TAS | biological_process |
| GO:0043687 | Post-translational protein modification | TAS | biological_process |
| GO:0044267 | Cellular protein metabolic process | TAS | biological_process |
| GO:0051787 | Misfolded protein binding | IDA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0652616808 | 0.3294097299 | 0.5505750962 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1563952244 |
| GSE13712_SHEAR | Down | -0.1911506099 |
| GSE13712_STATIC | Down | -0.0080029867 |
| GSE19018 | Up | 0.3105387191 |
| GSE19899_A1 | Up | 0.2695307281 |
| GSE19899_A2 | Up | 0.4822452130 |
| PubMed_21979375_A1 | Up | 0.4489040826 |
| PubMed_21979375_A2 | Up | 0.7606243612 |
| GSE35957 | Down | -0.2164446791 |
| GSE36640 | Up | 0.0156979211 |
| GSE54402 | Up | 0.5412915253 |
| GSE9593 | Up | 0.4323650221 |
| GSE43922 | Up | 0.6031223769 |
| GSE24585 | Down | -0.3683171765 |
| GSE37065 | Down | -0.1442223583 |
| GSE28863_A1 | Up | 0.2833984638 |
| GSE28863_A2 | Up | 0.2472727924 |
| GSE28863_A3 | Down | -0.8816228287 |
| GSE28863_A4 | Down | -0.4272809224 |
| GSE48662 | Down | -0.4954984857 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-204-5p | MIMAT0000265 | MIRT005824 | Luciferase reporter assay//Microarray//qRT-PCR | Functional MTI | 21282569 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT018268 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-32-5p | MIMAT0000090 | MIRT028385 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-125b-5p | MIMAT0000423 | MIRT046054 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-100-5p | MIMAT0000098 | MIRT048443 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-96-5p | MIMAT0000095 | MIRT048731 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
