HCSGD entry for UBE3C
1. General information
| Official gene symbol | UBE3C |
|---|---|
| Entrez ID | 9690 |
| Gene full name | ubiquitin protein ligase E3C |
| Other gene symbols | HECTH2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000209 | Protein polyubiquitination | IDA | biological_process |
| GO:0000502 | Proteasome complex | IEA | cellular_component |
| GO:0004842 | Ubiquitin-protein ligase activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005622 | Intracellular | IC | cellular_component |
| GO:0005634 | Nucleus | IBA | cellular_component |
| GO:0005737 | Cytoplasm | IBA | cellular_component |
| GO:0042787 | Protein ubiquitination involved in ubiquitin-dependent protein catabolic process | IBA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3131198017 | 0.9463010562 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0414136794 |
| GSE13712_SHEAR | Up | 0.3245946384 |
| GSE13712_STATIC | Up | 0.1020827677 |
| GSE19018 | Down | -0.1375129126 |
| GSE19899_A1 | Up | 0.0553239153 |
| GSE19899_A2 | Up | 0.3574740439 |
| PubMed_21979375_A1 | Up | 0.8565467058 |
| PubMed_21979375_A2 | Up | 0.3352399487 |
| GSE35957 | Up | 0.0370193338 |
| GSE36640 | Down | -0.0951365855 |
| GSE54402 | Up | 0.2698458910 |
| GSE9593 | Down | -0.1116453140 |
| GSE43922 | Up | 0.0433317023 |
| GSE24585 | Up | 0.0435900347 |
| GSE37065 | Down | -0.1507778273 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Up | 0.0213953020 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025444 | Proteomics | Functional MTI (Weak) | 21566225 |
| hsa-miR-7-5p | MIMAT0000252 | MIRT025738 | Microarray | Functional MTI (Weak) | 19073608 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029394 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-let-7g-5p | MIMAT0000414 | MIRT046557 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-10a-5p | MIMAT0000253 | MIRT047696 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-30c-5p | MIMAT0000244 | MIRT047843 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-17-5p | MIMAT0000070 | MIRT050883 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7a-5p | MIMAT0000062 | MIRT052374 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
