HCSGD entry for TGS1

1. General information

Official gene symbolTGS1
Entrez ID96764
Gene full nametrimethylguanosine synthase 1
Other gene symbolsNCOA6IP PIMT PIPMT
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000387Spliceosomal snRNP assemblyTASbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006355Regulation of transcription, DNA-templatedIEAbiological_process
GO:00094527-methylguanosine RNA cappingIEAbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0015030Cajal bodyIEAcellular_component
GO:0016070RNA metabolic processTASbiological_process
GO:0022613Ribonucleoprotein complex biogenesisICbiological_process
GO:0030532Small nuclear ribonucleoprotein complexICcellular_component
GO:0034660NcRNA metabolic processTASbiological_process
GO:00362617-methylguanosine cap hypermethylationIDAbiological_process
GO:0044255Cellular lipid metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0071164RNA trimethylguanosine synthase activityIDAmolecular_function
GO:0071167Ribonucleoprotein complex import into nucleusICbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.61329600320.23223632840.99999024730.9281471008

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1799447638
GSE13712_SHEARUp0.2277364736
GSE13712_STATICDown-0.0092090204
GSE19018Down-0.3918951459
GSE19899_A1Up0.1782321439
GSE19899_A2Up0.4119048414
PubMed_21979375_A1Down-0.2959468522
PubMed_21979375_A2Down-0.1068950724
GSE35957Down-0.2093112976
GSE36640Down-1.1699562888
GSE54402Up0.2143754062
GSE9593Down-0.0333402575
GSE43922Up0.1495112236
GSE24585Down-0.1331514817
GSE37065Up0.0653780274
GSE28863_A1Up0.0079479101
GSE28863_A2Up0.2599836041
GSE28863_A3Down-0.7627992446
GSE28863_A4Down-0.1873044776
GSE48662Down-0.1031118276

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-139-5pMIMAT0000250MIRT047774CLASHFunctional MTI (Weak)23622248
Entries Per Page
Displaying Page of
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 5 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24044898To minimize the damage, IsoAsp can be "repaired" by the protein l-isoaspartyl/d-aspartyl O-methyltransferase (PIMT) and S-adenosylmethionine (AdoMet) is the methyl donor of this reaction
24044898PIMT is a repair enzyme that initiates the conversion of l-isoAsp (or d-Asp) residues to l-Asp residues
18582478The protein l-isoaspartyl methyltransferase (PIMT) is involved in the repair of proteins containing abnormal L-isoaspartyl residues
18582478Although its mechanism of action is well defined, little is known about the pathways involved in the regulation of PIMT expression
18582478In this study, we demonstrated that glycogen synthase kinase-3 (GSK-3) and beta-catenin are involved in the regulation of PIMT expression
18582478PIMT induction by lithium was dependent on increased protein synthesis
18582478In addition, RT-PCR analysis showed higher level of PIMT mRNA following GSK-3 inhibition, which was abolished by the transcriptional inhibitor actinomycin D
18582478These results demonstrated regulation of PIMT expression by lithium at both the transcriptional and the translational levels
18582478Additionally, inhibition by siRNA of GSK-3 and beta-catenin modulated the expression of the PIMT in accordance with GSK-3 pharmacological inhibition
18582478Valproic acid, an antiepileptic drug with mood-stabilizing properties, up-regulated phospho-GSK-3beta (Ser9), beta-catenin and PIMT levels similarly to lithium
18582478This study reports that PIMT expression is up-regulated by GSK-3 inhibition and beta-catenin stabilization upon treatments with lithium and valproic acid
18582478These findings suggest a possible therapeutic role for PIMT in certain brain diseases including epilepsy
17892495Spontaneous protein deamidation of labile Asn residues, generating L-isoaspartates and D-aspartates, is associated with cell aging and is enhanced by an oxidative microenvironment; to minimize the damage, the isoaspartate residues can be 'repaired' by a specific L-isoaspartate (D-aspartate) protein O-methyltransferase (PIMT)
17892495Using recombinant PIMT as a probe, we demonstrated a dramatic rise of L-isoaspartates in erythrocyte membrane proteins from DS patients
17892495The integrity of the repair system was checked by evaluating methionine transport, PIMT specific activity, and intracellular concentrations of adenosylmethionine and adenosylhomocysteine
17167531The enzyme L-isoaspartyl methyltransferase (PIMT) is known to repair damaged proteins that have accumulated abnormal aspartyl residues during cell aging
17167531However, little is known about the mechanisms involved in the regulation of PIMT expression
17167531Here we report that PIMT expression in bovine aortic endothelial cells is regulated by cell detachment and readhesion to a substratum
17167531During cell detachment, the PIMT level was rapidly and strongly increased and correlated with a stimulation of protein synthesis
17167531Aside from endothelial cells, PIMT levels were also regulated by cell adhesion in various cancer cell lines
17167531The upregulation of PIMT expression could be prevented by an anti-alphavbeta3 antibody (LM609) or by a cyclic RGD peptide (XJ735) specific to integrin alphavbeta3, indicating that this integrin was likely involved in PIMT regulation
17167531This study reports new insights on the molecular mechanisms responsible for the regulation of PIMT expression in cells
17167531The regulation of PIMT level upon cell-substratum contact suggests a potential role for PIMT in biological processes such as wound healing, cell migration, and tumor metastasis dissemination
12390520Protein L-isoaspartyl methyltransferase (PIMT) repairs the damaged proteins which have accumulated abnormal aspartyl residues during cell aging
12390520Gene targeting has elucidated a physiological role for PIMT by showing that mice lacking PIMT died prematurely from fatal epileptic seizures
12390520Here we investigated the role of PIMT in human mesial temporal lobe epilepsy
12390520Using surgical specimens of hippocampus and neocortex from controls and epileptic patients, we showed that PIMT activity and expression were 50% lower in epileptic hippocampus than in controls but were unchanged in neocortex
12390520Although the protein was down-regulated, PIMT mRNA expression was unchanged in epileptic hippocampus, suggesting post-translational regulation of the PIMT level
12390520Microtubules component beta-tubulin, one of the major PIMT substrates, had an increased amount (two-fold) of L-isoaspartyl residues in the epileptic hippocampus
12390520These results demonstrate that the down-regulation of PIMT in epileptic hippocampus leads to a significant accumulation of damaged tubulin that could contribute to neuron dysfunction in human mesial temporal lobe epilepsy
Entries Per Page
Displaying Page of