HCSGD entry for EIF5B
1. General information
| Official gene symbol | EIF5B |
|---|---|
| Entrez ID | 9669 |
| Gene full name | eukaryotic translation initiation factor 5B |
| Other gene symbols | IF2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003743 | Translation initiation factor activity | IDA NAS | molecular_function |
| GO:0003924 | GTPase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005525 | GTP binding | IEA | molecular_function |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006412 | Translation | TAS | biological_process |
| GO:0006413 | Translational initiation | TAS | biological_process |
| GO:0006446 | Regulation of translational initiation | IDA NAS | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0044267 | Cellular protein metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0177397363 | 0.9759793283 | 0.3266206993 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.4296733846 |
| GSE13712_SHEAR | Up | 0.0837852961 |
| GSE13712_STATIC | Up | 0.1273107611 |
| GSE19018 | Down | -0.4310313886 |
| GSE19899_A1 | Up | 0.6430662575 |
| GSE19899_A2 | Up | 0.5417982761 |
| PubMed_21979375_A1 | Up | 0.4504696655 |
| PubMed_21979375_A2 | Up | 0.2679728748 |
| GSE35957 | Up | 0.0483132854 |
| GSE36640 | Up | 0.1321370986 |
| GSE54402 | Up | 0.2026674712 |
| GSE9593 | Up | 0.1483888784 |
| GSE43922 | Up | 0.2385923629 |
| GSE24585 | Down | -0.1343910734 |
| GSE37065 | Up | 0.0318034473 |
| GSE28863_A1 | Up | 0.5677453523 |
| GSE28863_A2 | Up | 0.9105628024 |
| GSE28863_A3 | Up | 0.3758599810 |
| GSE28863_A4 | Down | -0.0884468148 |
| GSE48662 | Down | -0.0455389208 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-16-5p | MIMAT0000069 | MIRT031635 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-484 | MIMAT0002174 | MIRT042049 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-15b-5p | MIMAT0000417 | MIRT046523 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
