HCSGD entry for DZIP3
1. General information
| Official gene symbol | DZIP3 |
|---|---|
| Entrez ID | 9666 |
| Gene full name | DAZ interacting zinc finger protein 3 |
| Other gene symbols | PPP1R66 UURF2 hRUL138 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000209 | Protein polyubiquitination | IDA | biological_process |
| GO:0003723 | RNA binding | IDA | molecular_function |
| GO:0004842 | Ubiquitin-protein ligase activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0019902 | Phosphatase binding | IDA | molecular_function |
| GO:0031593 | Polyubiquitin binding | IDA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9041097679 | 0.0034166217 | 0.9999902473 | 0.1187695652 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.4182032775 |
| GSE13712_SHEAR | Down | -0.3996080884 |
| GSE13712_STATIC | Up | 0.0194082554 |
| GSE19018 | Down | -0.1807898804 |
| GSE19899_A1 | Down | -0.6652149915 |
| GSE19899_A2 | Down | -1.5233492258 |
| PubMed_21979375_A1 | Down | -1.2468882601 |
| PubMed_21979375_A2 | Down | -1.2643414476 |
| GSE35957 | Down | -0.7659444580 |
| GSE36640 | Down | -0.6744262079 |
| GSE54402 | Down | -1.1510314219 |
| GSE9593 | Down | -0.4120125854 |
| GSE43922 | Down | -1.0129792895 |
| GSE24585 | Up | 0.7468572844 |
| GSE37065 | Down | -0.1619258088 |
| GSE28863_A1 | Up | 0.9018847620 |
| GSE28863_A2 | Up | 0.6194187126 |
| GSE28863_A3 | Down | -0.2805226176 |
| GSE28863_A4 | Down | -0.1341828712 |
| GSE48662 | Down | -0.0292590385 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-130b-5p | MIMAT0004680 | MIRT038320 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT048750 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24326307 | HOTAIR associates with E3 ubiquitin ligases bearing RNA-binding domains, Dzip3 and Mex3b, as well as with their respective ubiquitination substrates, Ataxin-1 and Snurportin-1 |
| 24326307 | In this manner, HOTAIR facilitates the ubiquitination of Ataxin-1 by Dzip3 and Snurportin-1 by Mex3b in cells and in vitro, and accelerates their degradation |
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