HCSGD entry for ARHGEF10

1. General information

Official gene symbolARHGEF10
Entrez ID9639
Gene full nameRho guanine nucleotide exchange factor (GEF) 10
Other gene symbolsGEF10
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005089Rho guanyl-nucleotide exchange factor activityIDA IEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005813CentrosomeIDAcellular_component
GO:0005829CytosolNAScellular_component
GO:0019894Kinesin bindingIPImolecular_function
GO:0022011Myelination in peripheral nervous systemIMPbiological_process
GO:0032318Regulation of Ras GTPase activityIDAbiological_process
GO:0032319Regulation of Rho GTPase activityIDAbiological_process
GO:0033126Positive regulation of GTP catabolic processIDAbiological_process
GO:0043087Regulation of GTPase activityIDAbiological_process
GO:0051298Centrosome duplicationIMPbiological_process
GO:0051496Positive regulation of stress fiber assemblyIMPbiological_process
GO:0090307Spindle assembly involved in mitosisIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.87740637130.07379433530.99999024730.5120856051

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1944399108
GSE13712_SHEARUp0.4176078811
GSE13712_STATICUp0.0442690225
GSE19018Down-0.3557698943
GSE19899_A1Down-0.2818130825
GSE19899_A2Down-0.3040445817
PubMed_21979375_A1Down-0.5573738508
PubMed_21979375_A2Down-0.5128384989
GSE35957Down-0.2738307331
GSE36640Down-0.0671491289
GSE54402Down-0.3282322955
GSE9593Down-0.3711764901
GSE43922Down-0.1917433170
GSE24585Down-0.0713949630
GSE37065Down-0.3026237072
GSE28863_A1Up0.2721346231
GSE28863_A2Up0.3955400942
GSE28863_A3Up0.0873378401
GSE28863_A4Up0.0587926716
GSE48662Up0.2624126848

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-9-5pMIMAT0000441MIRT021449MicroarrayFunctional MTI (Weak)17612493
hsa-miR-192-5pMIMAT0000222MIRT026698MicroarrayFunctional MTI (Weak)19074876
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.