HCSGD entry for AATK
1. General information
| Official gene symbol | AATK |
|---|---|
| Entrez ID | 9625 |
| Gene full name | apoptosis-associated tyrosine kinase |
| Other gene symbols | AATYK AATYK1 LMR1 LMTK1 p35BP |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004674 | Protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0004713 | Protein tyrosine kinase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0005783 | Endoplasmic reticulum | IEA | cellular_component |
| GO:0007420 | Brain development | IEA | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0030517 | Negative regulation of axon extension | IEA | biological_process |
| GO:0032482 | Rab protein signal transduction | IEA | biological_process |
| GO:0038083 | Peptidyl-tyrosine autophosphorylation | IEA | biological_process |
| GO:0044295 | Axonal growth cone | IEA | cellular_component |
| GO:0048471 | Perinuclear region of cytoplasm | IEA | cellular_component |
| GO:0051402 | Neuron apoptotic process | IEA | biological_process |
| GO:0055037 | Recycling endosome | IEA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1864419855 | 0.8710376847 | 0.8423171129 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.4034740092 |
| GSE13712_SHEAR | Up | 0.8465835347 |
| GSE13712_STATIC | Up | 0.3768488160 |
| GSE19018 | Up | 0.1721560788 |
| GSE19899_A1 | Down | -0.0790424643 |
| GSE19899_A2 | Up | 0.3372077394 |
| PubMed_21979375_A1 | Up | 0.1126007349 |
| PubMed_21979375_A2 | Down | -0.2072869856 |
| GSE35957 | Up | 0.2334994337 |
| GSE36640 | Down | -0.0333780896 |
| GSE54402 | Down | -0.0248291467 |
| GSE9593 | Up | 0.1258832492 |
| GSE43922 | Up | 0.1064659120 |
| GSE24585 | Down | -0.0389533862 |
| GSE37065 | Down | -0.0225972035 |
| GSE28863_A1 | Up | 0.0017578772 |
| GSE28863_A2 | Up | 0.0652862474 |
| GSE28863_A3 | Up | 0.3743825413 |
| GSE28863_A4 | Up | 0.1048463684 |
| GSE48662 | Up | 0.0661712992 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018823 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
