HCSGD entry for NCOR2

1. General information

Official gene symbolNCOR2
Entrez ID9612
Gene full namenuclear receptor corepressor 2
Other gene symbolsCTG26 N-CoR2 SMAP270 SMRT SMRTE SMRTE-tau TNRC14 TRAC TRAC-1 TRAC1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000118Histone deacetylase complexIEAcellular_component
GO:0000122Negative regulation of transcription from RNA polymerase II promoterIDA IEA IMP TASbiological_process
GO:0000785ChromatinIEAcellular_component
GO:0001012RNA polymerase II regulatory region DNA bindingIEAmolecular_function
GO:0001701In utero embryonic developmentIEAbiological_process
GO:0003007Heart morphogenesisIEAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0003682Chromatin bindingIEAmolecular_function
GO:0003714Transcription corepressor activityIDA IEA IMPmolecular_function
GO:0005112Notch bindingIPImolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIC IDA IEAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005730NucleolusIDAcellular_component
GO:0006351Transcription, DNA-templatedTASbiological_process
GO:0006367Transcription initiation from RNA polymerase II promoterTASbiological_process
GO:0007179Transforming growth factor beta receptor signaling pathwayTASbiological_process
GO:0007219Notch signaling pathwayTASbiological_process
GO:0007595LactationIEAbiological_process
GO:0010243Response to organonitrogen compoundIEAbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0016363Nuclear matrixIDAcellular_component
GO:0016604Nuclear bodyIDA IEAcellular_component
GO:0016922Ligand-dependent nuclear receptor bindingIEAmolecular_function
GO:0017053Transcriptional repressor complexIDAcellular_component
GO:0021537Telencephalon developmentIEAbiological_process
GO:0021846Cell proliferation in forebrainIEAbiological_process
GO:0032355Response to estradiolIEAbiological_process
GO:0032403Protein complex bindingIEAmolecular_function
GO:0035259Glucocorticoid receptor bindingIEAmolecular_function
GO:0042593Glucose homeostasisIEAbiological_process
GO:0042826Histone deacetylase bindingIPImolecular_function
GO:0043565Sequence-specific DNA bindingIEAmolecular_function
GO:0044255Cellular lipid metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045599Negative regulation of fat cell differentiationIEAbiological_process
GO:0046965Retinoid X receptor bindingIEAmolecular_function
GO:0047485Protein N-terminus bindingIPImolecular_function
GO:0050872White fat cell differentiationIEAbiological_process
GO:0060206Estrous cycle phaseIEAbiological_process
GO:0060509Type I pneumocyte differentiationIEAbiological_process
GO:0072365Regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoterIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.40725966720.66902119220.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1656596888
GSE13712_SHEARUp0.5982762980
GSE13712_STATICUp0.5350832362
GSE19018Up0.0983870883
GSE19899_A1Down-0.0184760667
GSE19899_A2Up0.1747570315
PubMed_21979375_A1Up0.3022614015
PubMed_21979375_A2Up0.1901704460
GSE35957Down-0.1076840653
GSE36640Down-0.0456916212
GSE54402Up0.0952283457
GSE9593Down-0.0637541424
GSE43922Up0.0316051390
GSE24585Down-0.2235825371
GSE37065Down-0.2268329941
GSE28863_A1Up0.0052405543
GSE28863_A2Up0.0778108929
GSE28863_A3Up0.2330616380
GSE28863_A4Up0.0228202307
GSE48662Down-0.2630871946

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-10a-5pMIMAT0000253MIRT005454qRT-PCR//Western blotFunctional MTI21212796
hsa-miR-10b-5pMIMAT0000254MIRT005455qRT-PCR//Western blotFunctional MTI21212796
hsa-miR-16-5pMIMAT0000069MIRT006651Luciferase reporter assayFunctional MTI22292036
hsa-miR-9-5pMIMAT0000441MIRT021376MicroarrayFunctional MTI (Weak)17612493
hsa-miR-2110MIMAT0010133MIRT035758CLASHFunctional MTI (Weak)23622248
hsa-miR-130b-5pMIMAT0004680MIRT038284CLASHFunctional MTI (Weak)23622248
hsa-miR-20a-5pMIMAT0000075MIRT050519CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

17316622Oct-1 specifically interacts with this binding site in vitro and in vivo and SMRT and HDAC1 are present in the p15(INK4b) proximal promoter region
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