HCSGD entry for AKAP12
1. General information
| Official gene symbol | AKAP12 |
|---|---|
| Entrez ID | 9590 |
| Gene full name | A kinase (PRKA) anchor protein 12 |
| Other gene symbols | AKAP250 SSeCKS |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005856 | Cytoskeleton | IEA | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0005938 | Cell cortex | IEA | cellular_component |
| GO:0006605 | Protein targeting | IEA | biological_process |
| GO:0007186 | G-protein coupled receptor signaling pathway | TAS | biological_process |
| GO:0008179 | Adenylate cyclase binding | IPI | molecular_function |
| GO:0010739 | Positive regulation of protein kinase A signaling | IMP | biological_process |
| GO:0030819 | Positive regulation of cAMP biosynthetic process | IMP | biological_process |
| GO:0051018 | Protein kinase A binding | IEA | molecular_function |
| GO:0090036 | Regulation of protein kinase C signaling | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0148135139 | 0.3150255651 | 0.3031932348 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2429585449 |
| GSE13712_SHEAR | Up | 0.4876943734 |
| GSE13712_STATIC | Down | -0.1655541131 |
| GSE19018 | Down | -0.3188089954 |
| GSE19899_A1 | Up | 0.8792997359 |
| GSE19899_A2 | Up | 0.0461373094 |
| PubMed_21979375_A1 | Up | 0.0576848741 |
| PubMed_21979375_A2 | Up | 0.5096495173 |
| GSE35957 | Down | -0.2171582117 |
| GSE36640 | Down | -1.2927023351 |
| GSE54402 | Up | 0.3429489237 |
| GSE9593 | Down | -0.2952624876 |
| GSE43922 | Up | 0.6650556530 |
| GSE24585 | Down | -0.4510420406 |
| GSE37065 | Up | 0.5306971383 |
| GSE28863_A1 | Up | 0.9760278111 |
| GSE28863_A2 | Up | 0.4008104155 |
| GSE28863_A3 | Up | 0.3794181172 |
| GSE28863_A4 | Down | -0.0357286364 |
| GSE48662 | Up | 0.1355999127 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-183-5p | MIMAT0000261 | MIRT005870 | Immunohistochemistry//Luciferase reporter assay//Microarray//qRT-PCR//Western blot | Functional MTI | 20979053 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT005871 | Immunohistochemistry//Luciferase reporter assay//Microarray//qRT-PCR//Western blot | Functional MTI | 20979053 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT005871 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-1 | MIMAT0000416 | MIRT023602 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-877-3p | MIMAT0004950 | MIRT036840 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-181a-5p | MIMAT0000256 | MIRT047327 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22811901 | Pivotal Role of AKAP12 in the Regulation of Cellular Adhesion Dynamics: Control of Cytoskeletal Architecture, Cell Migration, and Mitogenic Signaling |
| 22811901 | AKAP12/SSeCKS/Gravin (AKAP12) is a scaffold protein for PKA and PKC which controls actin-cytoskeleton reorganization in a spatiotemporal manner |
| 22811901 | AKAP12 also acts as a tumor suppressor which regulates cell-cycle progression and inhibits Src-mediated oncogenic signaling and cytoskeletal pathways |
| 22811901 | Downregulation of AKAP12 induces the formation of thickened, longitudinal stress fibers and the proliferation of adhesion complexes |
| 22811901 | AKAP12-null mouse embryonic fibroblasts exhibit hyperactivation of PKC, premature cellular senescence, and defects in cytokinesis, relating to the loss of PKC scaffolding activity by AKAP12 |
| 22811901 | The paper describes the regulatory and scaffolding functions of AKAP12 and how it regulates cell adhesion, signaling, and oncogenic suppression |
| 22684366 | Scaffolding proteins such as SSeCKS/Gravin/AKAP12 ("AKAP12") are thought to control oncogenic signaling pathways by regulating key mediators in a spatiotemporal manner |
| 22684366 | The downregulation of AKAP12 in many human cancers, often associated with promoter hypermethylation, or the loss of its locus at 6q24-25 |
| 22684366 | The forced re-expression of AKAP12 in cancer cell lines suppresses in vitro parameters of oncogenic growth, invasiveness, and cell motility through its ability to scaffold protein kinase C (PKC), F-actin, cyclins, Src, and phosphoinositides, and possibly through additional scaffolding domains for PKA, calmodulin, beta1,4-galactosyltransferase-polypeptide-1, beta2-adrenergic receptors, and cAMP-specific 3',5'-cyclic phosphodiesterase 4D |
| 22684366 | Moreover, AKAP12 re-expression in tumor models results in metastasis suppression through the inhibition of Src-regulated, VEGF-mediated neovascularization at distal sites |
| 21779438 | Emerging data suggest that SSeCKS/Gravin/AKAP12 ("AKAP12"), originally identified as an autoantigen in cases of myasthenia gravis, controls multiple biological processes through its ability to scaffold key signaling proteins such as protein kinase (PK) C and A, calmodulin, cyclins, phosphoinositides, "long" beta-1,4 galactosyltransferase (GalTase) isoform, Src, as well as the actin cytoskeleton in a spatiotemporal manner |
| 21779438 | Specialized functions attributed to AKAP12 include the suppression of cancer malignancy, especially aspects of metastatic progression, regulation of blood-brain and blood-retina barrier formation, and resensitization of beta2-adrenergic pain receptors |
| 21779438 | Recent data identify a direct role for AKAP12 in cytokinesis completion, further suggesting a function as a negative regulator of cell senescence |
| 21779438 | The current review will discuss the emerging knowledge base of AKAP12-related biological roles and how the factors that affect AKAP12 expression or that interact with AKAP12 at the protein level control cancer progression and blood-tissue barrier formation |
| 21099353 | Rb-dependent cellular senescence, multinucleation and susceptibility to oncogenic transformation through PKC scaffolding by SSeCKS/AKAP12 |
| 21099353 | Although p53 and Rb pathways are activated in the absence of Akap12, senescence is dependent on Rb |
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