HCSGD entry for CD40

1. General information

Official gene symbolCD40
Entrez ID958
Gene full nameCD40 molecule, TNF receptor superfamily member 5
Other gene symbolsBp50 CDW40 TNFRSF5 p50
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001934Positive regulation of protein phosphorylationIMPbiological_process
GO:0002768Immune response-regulating cell surface receptor signaling pathwayIEAbiological_process
GO:0003823Antigen bindingIEAmolecular_function
GO:0004871Signal transducer activityTASmolecular_function
GO:0004872Receptor activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005615Extracellular spaceIEAcellular_component
GO:0005737CytoplasmIEAcellular_component
GO:0005886Plasma membraneISS TAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0006461Protein complex assemblyTASbiological_process
GO:0006874Cellular calcium ion homeostasisIMPbiological_process
GO:0006954Inflammatory responseIEAbiological_process
GO:0009897External side of plasma membraneIEAcellular_component
GO:0019899Enzyme bindingIPImolecular_function
GO:0030168Platelet activationNASbiological_process
GO:0030890Positive regulation of B cell proliferationIEAbiological_process
GO:0031625Ubiquitin protein ligase bindingIPImolecular_function
GO:0032735Positive regulation of interleukin-12 productionIEAbiological_process
GO:0032855Positive regulation of Rac GTPase activityIMPbiological_process
GO:0035631CD40 receptor complexISScellular_component
GO:0042100B cell proliferationNASbiological_process
GO:0042511Positive regulation of tyrosine phosphorylation of Stat1 proteinIMPbiological_process
GO:0043089Positive regulation of Cdc42 GTPase activityIMPbiological_process
GO:0043123Positive regulation of I-kappaB kinase/NF-kappaB signalingIEPbiological_process
GO:0043231Intracellular membrane-bounded organelleIEAcellular_component
GO:0043406Positive regulation of MAP kinase activityIMPbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIMPbiological_process
GO:0048304Positive regulation of isotype switching to IgG isotypesIEAbiological_process
GO:0050776Regulation of immune responseTASbiological_process
GO:0051023Regulation of immunoglobulin secretionIEAbiological_process
GO:0051092Positive regulation of NF-kappaB transcription factor activityIMPbiological_process
GO:0051607Defense response to virusIEAbiological_process
GO:0071222Cellular response to lipopolysaccharideIEAbiological_process
GO:0071260Cellular response to mechanical stimulusIEPbiological_process
GO:0090037Positive regulation of protein kinase C signalingIMPbiological_process
GO:2000353Positive regulation of endothelial cell apoptotic processIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.73116429090.18068912280.99999024730.8233930748

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0041831848
GSE13712_SHEARDown-1.5173187621
GSE13712_STATICDown-1.2049770358
GSE19018Up0.0598228765
GSE19899_A1Up0.1095741415
GSE19899_A2Up0.0396799550
PubMed_21979375_A1Down-0.1622689832
PubMed_21979375_A2Down-0.0963436139
GSE35957Down-0.3415843130
GSE36640Down-0.0380114760
GSE54402Up0.1642322705
GSE9593Up0.4559790466
GSE43922Up0.0106863126
GSE24585Up0.2720149538
GSE37065Up0.4358733997
GSE28863_A1Down-0.2228155192
GSE28863_A2Down-0.0960160682
GSE28863_A3Up0.1455071694
GSE28863_A4Up0.0858030214
GSE48662Up0.0078741378

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-224-5pMIMAT0000281MIRT003393Microarray//qRT-PCRFunctional MTI (Weak)19475450
hsa-miR-486-5pMIMAT0002177MIRT004620Microarray//qRT-PCRFunctional MTI (Weak)19475450
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

19737142Macrophage activation was studied by CD40 antigen expression
19493573Trophoblast cells and many cancer cells that harbor foreign antigens may evade immunity by epigenetic silencing of key immune response genes, including MHC class I and II and CD40
19493573We show here that pre-treatment of trophoblast cells and certain cancer cells with agents that activate stress pathways (Ras oncogene, PMA or H2O2) and induce senescence can substantially enhance the induction of immune response genes (MHC class II, CD40, MICA, MICB) by HDACi and restore a vigorous IFN-gamma response in trophoblast cells and tumor cells
11465672Measurement of temolerase activity in cell lysates showed a rapid up-regulation of telomerase following the initiation of the culture that was dependent on the CD40 signaling
9233598In vitro stimulation of human memory B cells through surface Ig or CD40 was capable of up-regulating telomerase
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