HCSGD entry for H6PD
1. General information
| Official gene symbol | H6PD |
|---|---|
| Entrez ID | 9563 |
| Gene full name | hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) |
| Other gene symbols | CORTRD1 G6PDH GDH |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004345 | Glucose-6-phosphate dehydrogenase activity | IEA | molecular_function |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0005788 | Endoplasmic reticulum lumen | IEA | cellular_component |
| GO:0006098 | Pentose-phosphate shunt | IEA | biological_process |
| GO:0017057 | 6-phosphogluconolactonase activity | IEA | molecular_function |
| GO:0030246 | Carbohydrate binding | IEA | molecular_function |
| GO:0047936 | Glucose 1-dehydrogenase [NAD(P)] activity | IEA | molecular_function |
| GO:0050661 | NADP binding | IEA | molecular_function |
| GO:0097305 | Response to alcohol | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1351910490 | 0.9114699555 | 0.7433389597 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2631657875 |
| GSE13712_SHEAR | Up | 0.2821340542 |
| GSE13712_STATIC | Up | 0.5401899920 |
| GSE19018 | Up | 0.1736274063 |
| GSE19899_A1 | Up | 0.1336381965 |
| GSE19899_A2 | Up | 0.3816814284 |
| PubMed_21979375_A1 | Down | -0.1934965337 |
| PubMed_21979375_A2 | Up | 0.3776836441 |
| GSE35957 | Up | 0.1228961149 |
| GSE36640 | Down | -0.0109754996 |
| GSE54402 | Up | 0.4478362498 |
| GSE9593 | Down | -0.0138857604 |
| GSE43922 | Up | 0.0720097258 |
| GSE24585 | Up | 0.1128318680 |
| GSE37065 | Down | -0.3756942439 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Up | 0.1509497906 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| NADH | DB00157 | NUTR00041 | DB01907 | EXPT02287 | DB03527 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018427 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT022903 | Microarray | Functional MTI (Weak) | 18668037 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 1531948 | The relationship between the number of CR1/E and cell age was analysed by measuring G6PDH activity in E that had been sorted according to high or low expression of CR1 (CD35), by assessing the expression of CR1 (CD35) on E separated according to cell density, and by comparing the number of CR1 (CD35) antigenic sites on reticulocytes and on E |
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