HCSGD entry for POLR1C

1. General information

Official gene symbolPOLR1C
Entrez ID9533
Gene full namepolymerase (RNA) I polypeptide C, 30kDa
Other gene symbolsRPA39 RPA40 RPA5 RPAC1 TCS3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001054RNA polymerase I activityIBAmolecular_function
GO:0001056RNA polymerase III activityIBAmolecular_function
GO:0003677DNA bindingIEAmolecular_function
GO:0003899DNA-directed RNA polymerase activityIEA TASmolecular_function
GO:0005654NucleoplasmTAScellular_component
GO:0005666DNA-directed RNA polymerase III complexIBAcellular_component
GO:0005736DNA-directed RNA polymerase I complexTAScellular_component
GO:0005829CytosolTAScellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006360Transcription from RNA polymerase I promoterTASbiological_process
GO:0006361Transcription initiation from RNA polymerase I promoterTASbiological_process
GO:0006362Transcription elongation from RNA polymerase I promoterTASbiological_process
GO:0006363Termination of RNA polymerase I transcriptionTASbiological_process
GO:0006383Transcription from RNA polymerase III promoterTASbiological_process
GO:0006385Transcription elongation from RNA polymerase III promoterTASbiological_process
GO:0006386Termination of RNA polymerase III transcriptionTASbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0032481Positive regulation of type I interferon productionTASbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0046983Protein dimerization activityIEAmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.02172496490.58614643440.35493269231.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.3479797681
GSE13712_SHEARUp0.2846839336
GSE13712_STATICUp0.3733875212
GSE19018Down-0.7620171031
GSE19899_A1Up0.6722578354
GSE19899_A2Up1.3761461506
PubMed_21979375_A1Up1.6555685181
PubMed_21979375_A2Up0.4604035615
GSE35957Down-0.5335068886
GSE36640Down-0.3200743233
GSE54402Up0.7421297684
GSE9593Down-0.1885368918
GSE43922Up0.6545889890
GSE24585Up0.0094261230
GSE37065Down-0.2047266036
GSE28863_A1Down-0.0624276869
GSE28863_A2Up0.1082488214
GSE28863_A3Down-0.1671257762
GSE28863_A4Down-0.0583373865
GSE48662Down-0.2923134852

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-16-5pMIMAT0000069MIRT032027ProteomicsFunctional MTI (Weak)18668040
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.