HCSGD entry for ENTPD1
1. General information
| Official gene symbol | ENTPD1 |
|---|---|
| Entrez ID | 953 |
| Gene full name | ectonucleoside triphosphate diphosphohydrolase 1 |
| Other gene symbols | ATPDase CD39 NTPDase-1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005605 | Basal lamina | IEA | cellular_component |
| GO:0005886 | Plasma membrane | NAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | TAS | cellular_component |
| GO:0006200 | ATP catabolic process | IEA | biological_process |
| GO:0007155 | Cell adhesion | NAS | biological_process |
| GO:0007186 | G-protein coupled receptor signaling pathway | IEA | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0009181 | Purine ribonucleoside diphosphate catabolic process | IEA | biological_process |
| GO:0017110 | Nucleoside-diphosphatase activity | IEA | molecular_function |
| GO:0017111 | Nucleoside-triphosphatase activity | IEA | molecular_function |
| GO:0030168 | Platelet activation | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8473098514 | 0.0255532617 | 0.9999902473 | 0.3071175342 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1368201012 |
| GSE13712_SHEAR | Down | -5.4862297069 |
| GSE13712_STATIC | Down | -3.6177614753 |
| GSE19018 | Up | 0.0359063368 |
| GSE19899_A1 | Up | 0.0389546962 |
| GSE19899_A2 | Up | 0.0054372288 |
| PubMed_21979375_A1 | Down | -0.0886889565 |
| PubMed_21979375_A2 | Down | -0.0149595644 |
| GSE35957 | Down | -0.1214005966 |
| GSE36640 | Up | 0.1153104480 |
| GSE54402 | Up | 0.0201404354 |
| GSE9593 | Down | -0.6513639121 |
| GSE43922 | Up | 0.0311329338 |
| GSE24585 | Up | 0.5093515872 |
| GSE37065 | Up | 0.0325839410 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Up | 0.1262417804 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-346 | MIMAT0000773 | MIRT004222 | Microarray | Functional MTI (Weak) | 16822819 |
| hsa-miR-331-3p | MIMAT0000760 | MIRT043272 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23964074 | The P2X7R was expressed on apical and basolateral membranes of mouse RPE; mRNA expression of P2X7R and extracellular ATP marker NTPDase1 was raised in RPE tissue from the ABCA4(-/-) mouse model of Stargardt's retinal degeneration |
| 23804221 | CONCLUSION: Our findings indicate that the combination of CD73 and CD39 allows the prospective purification from culture-expanded heterogeneous synovial MSC populations of a distinct MSC subset with greater chondro-osteogenic potency |
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