HCSGD entry for EEF1E1
1. General information
| Official gene symbol | EEF1E1 |
|---|---|
| Entrez ID | 9521 |
| Gene full name | eukaryotic translation elongation factor 1 epsilon 1 |
| Other gene symbols | AIMP3 P18 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA ISS | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA ISS | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006418 | TRNA aminoacylation for protein translation | TAS | biological_process |
| GO:0008285 | Negative regulation of cell proliferation | ISS | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0043065 | Positive regulation of apoptotic process | ISS | biological_process |
| GO:0043517 | Positive regulation of DNA damage response, signal transduction by p53 class mediator | ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1073796854 | 0.1941559553 | 0.6803901541 | 0.8535792383 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3611374988 |
| GSE13712_SHEAR | Up | 0.4534659591 |
| GSE13712_STATIC | Up | 0.1264068462 |
| GSE19018 | Down | -1.2434877835 |
| GSE19899_A1 | Up | 0.0220992212 |
| GSE19899_A2 | Down | -0.2333985543 |
| PubMed_21979375_A1 | Up | 0.3472763381 |
| PubMed_21979375_A2 | Down | -0.1514314935 |
| GSE35957 | Down | -0.1637041727 |
| GSE36640 | Down | -0.6589562069 |
| GSE54402 | Up | 0.6418125085 |
| GSE9593 | Down | -0.3204462975 |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | Up | 0.1121108237 |
| GSE28863_A2 | Up | 0.5199728832 |
| GSE28863_A3 | Up | 0.6028285268 |
| GSE28863_A4 | Up | 0.0220090984 |
| GSE48662 | Down | -0.4096639221 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-155-5p | MIMAT0000646 | MIRT020944 | Proteomics | Functional MTI (Weak) | 19136465 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT032471 | Proteomics | Functional MTI (Weak) | 18668040 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25465621 | In this study, we report a novel role of AIMP3/p18 in the cellular aging of human mesenchymal stem cells (hMSCs) |
| 25465621 | We found that AIMP3/p18 expression significantly increased in senescent hMSCs and in aged mouse bone marrow-derived MSCs (mBM-MSCs) |
| 25465621 | AIMP3/p18 overexpression is sufficient to induce the cellular senescence phenotypes with compromised clonogenicity and adipogenic differentiation potential |
| 25465621 | To identify the upstream regulators of AIMP3/p18 during senescence, we screened for potential epigenetic regulators and for miRNAs |
| 25465621 | We found that the levels of miR-543 and miR-590-3p significantly decreased under senescence-inducing conditions, whereas the AIMP3/p18 protein levels increased |
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