HCSGD entry for GDF15
1. General information
| Official gene symbol | GDF15 |
|---|---|
| Entrez ID | 9518 |
| Gene full name | growth differentiation factor 15 |
| Other gene symbols | GDF-15 MIC-1 MIC1 NAG-1 PDF PLAB PTGFB |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005125 | Cytokine activity | IEA | molecular_function |
| GO:0005576 | Extracellular region | TAS | cellular_component |
| GO:0005615 | Extracellular space | IEA | cellular_component |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0007179 | Transforming growth factor beta receptor signaling pathway | TAS | biological_process |
| GO:0007267 | Cell-cell signaling | TAS | biological_process |
| GO:0008083 | Growth factor activity | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0000303788 | 0.9976545800 | 0.0154792453 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 1.8659205850 |
| GSE13712_SHEAR | Up | 0.4396685630 |
| GSE13712_STATIC | Up | 0.4778383669 |
| GSE19018 | Up | 0.2461636277 |
| GSE19899_A1 | Up | 1.5378083953 |
| GSE19899_A2 | Up | 2.7097192569 |
| PubMed_21979375_A1 | Up | 4.4174827444 |
| PubMed_21979375_A2 | Up | 2.1625828855 |
| GSE35957 | Down | -0.2971195822 |
| GSE36640 | Up | 1.3037013575 |
| GSE54402 | Up | 0.5724332872 |
| GSE9593 | Up | 0.6598521623 |
| GSE43922 | Up | 2.5979090740 |
| GSE24585 | Up | 0.6645844383 |
| GSE37065 | Up | 0.5264664124 |
| GSE28863_A1 | Down | -0.1732392988 |
| GSE28863_A2 | Down | -0.0042071740 |
| GSE28863_A3 | Up | 0.4751312511 |
| GSE28863_A4 | Up | 0.0431114089 |
| GSE48662 | Up | 1.9283948081 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018703 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26909594 | GDF15 contributes to radiation-induced senescence through the ROS-mediated p16 pathway in human endothelial cells |
| 26909594 | Growth differentiation factor 15 (GDF15) is an emerging biomarker of cardiovascular risk and disease |
| 26909594 | Microarray analyses revealed that GDF15 levels were increased during cellular senescence induced by ionizing radiation (IR) in human aortic endothelial cells (HAECs) |
| 26909594 | However, the role of GDF15 in HAEC cellular senescence remains unclear |
| 26909594 | This study demonstrated that downregulation of GDF15 in HAECs partially prevented cellular senescence triggered by IR, which was confirmed by recovery of cell proliferation and reverse senescence-associated beta-galactosidase (SA-beta-gal) staining |
| 26909594 | GDF15 expression in endothelial cells also generated reactive oxygen species (ROS), which led to activation of extracellular signal-regulated kinases (ERKs) and induction of senescence by oxidative stress |
| 18202802 | Induction of apoptosis by pectenotoxin-2 is mediated with the induction of DR4/DR5, Egr-1 and NAG-1, activation of caspases and modulation of the Bcl-2 family in p53-deficient Hep3B hepatocellular carcinoma cells |
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