HCSGD entry for ADAMTS4
1. General information
| Official gene symbol | ADAMTS4 |
|---|---|
| Entrez ID | 9507 |
| Gene full name | ADAM metallopeptidase with thrombospondin type 1 motif, 4 |
| Other gene symbols | ADAMTS-2 ADAMTS-4 ADMP-1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001501 | Skeletal system development | TAS | biological_process |
| GO:0002020 | Protease binding | IPI | molecular_function |
| GO:0004222 | Metalloendopeptidase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005578 | Proteinaceous extracellular matrix | IEA | cellular_component |
| GO:0005615 | Extracellular space | IDA | cellular_component |
| GO:0006508 | Proteolysis | IEA | biological_process |
| GO:0008233 | Peptidase activity | TAS | molecular_function |
| GO:0008237 | Metallopeptidase activity | TAS | molecular_function |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0703930702 | 0.9221621899 | 0.5668107984 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0721175537 |
| GSE13712_SHEAR | Up | 0.7805857853 |
| GSE13712_STATIC | Up | 0.2785040165 |
| GSE19018 | Up | 0.1198885470 |
| GSE19899_A1 | Up | 0.0178723958 |
| GSE19899_A2 | Up | 0.1025962220 |
| PubMed_21979375_A1 | Up | 0.1430931740 |
| PubMed_21979375_A2 | Down | -0.1264095869 |
| GSE35957 | Up | 0.1043218003 |
| GSE36640 | Up | 0.0805911411 |
| GSE54402 | Up | 0.1884956457 |
| GSE9593 | Down | -0.0263506312 |
| GSE43922 | Up | 0.5257794633 |
| GSE24585 | Down | -0.0022152087 |
| GSE37065 | Up | 0.4775153460 |
| GSE28863_A1 | Down | -0.1321349729 |
| GSE28863_A2 | Up | 0.4533140999 |
| GSE28863_A3 | Up | 0.2296118782 |
| GSE28863_A4 | Up | 0.0578730044 |
| GSE48662 | Down | -0.2377814521 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-148b-3p | MIMAT0000759 | MIRT019411 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-128-3p | MIMAT0000424 | MIRT022022 | Microarray | Functional MTI (Weak) | 17612493 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23262094 | Expression of the protease ADAMTS4 and aggrecan proteolytic fragments was significantly increased |
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