HCSGD entry for TBX4
1. General information
| Official gene symbol | TBX4 |
|---|---|
| Entrez ID | 9496 |
| Gene full name | T-box 4 |
| Other gene symbols | SPS |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001525 | Angiogenesis | IEA | biological_process |
| GO:0002009 | Morphogenesis of an epithelium | IEA | biological_process |
| GO:0003677 | DNA binding | IEA NAS | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA TAS | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | NAS | biological_process |
| GO:0007275 | Multicellular organismal development | NAS | biological_process |
| GO:0030324 | Lung development | IEA | biological_process |
| GO:0030326 | Embryonic limb morphogenesis | IEA | biological_process |
| GO:0035108 | Limb morphogenesis | IMP | biological_process |
| GO:0048705 | Skeletal system morphogenesis | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6334969454 | 0.8302387523 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0822657731 |
| GSE13712_SHEAR | Up | 0.3325762077 |
| GSE13712_STATIC | Down | -0.0446645986 |
| GSE19018 | Down | -0.0341634247 |
| GSE19899_A1 | Up | 0.0324401485 |
| GSE19899_A2 | Up | 0.0022942300 |
| PubMed_21979375_A1 | Down | -0.0776172114 |
| PubMed_21979375_A2 | Down | -0.0621185251 |
| GSE35957 | Down | -0.0174798828 |
| GSE36640 | Down | -0.0560797755 |
| GSE54402 | Down | -0.2694599891 |
| GSE9593 | Up | 0.1804001953 |
| GSE43922 | Up | 0.0982320750 |
| GSE24585 | Up | 0.1074843681 |
| GSE37065 | Down | -0.1357831232 |
| GSE28863_A1 | Down | -0.0611195617 |
| GSE28863_A2 | Down | -0.0431028614 |
| GSE28863_A3 | Up | 0.2123178054 |
| GSE28863_A4 | Up | 0.1477583551 |
| GSE48662 | Up | 0.0218381334 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-181a-5p | MIMAT0000256 | MIRT025176 | Microarray | Functional MTI (Weak) | 17612493 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 15136151 | We found significant repression of Tbx2 and Tbx3, both linked to inhibition of cellular senescence, in Shh(-/-) and partial derepression in Shh(-/-); Gli3(-/-) lungs, while Tbx4 and Tbx5 expressions are less affected in the mutants |
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