HCSGD entry for CD36

1. General information

Official gene symbolCD36
Entrez ID948
Gene full nameCD36 molecule (thrombospondin receptor)
Other gene symbolsBDPLT10 CHDS7 FAT GP3B GP4 GPIV PASIV SCARB3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0001954Positive regulation of cell-matrix adhesionIDAbiological_process
GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0002474Antigen processing and presentation of peptide antigen via MHC class ITASbiological_process
GO:0002479Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentTASbiological_process
GO:0002576Platelet degranulationTASbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0005041Low-density lipoprotein receptor activityIEA IMP TASmolecular_function
GO:0005794Golgi apparatusIEAcellular_component
GO:0005886Plasma membraneIDA TAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0006629Lipid metabolic processNASbiological_process
GO:0006898Receptor-mediated endocytosisIMP TASbiological_process
GO:0006910Phagocytosis, recognitionIEAbiological_process
GO:0007155Cell adhesionIEAbiological_process
GO:0007166Cell surface receptor signaling pathwayIEAbiological_process
GO:0007263Nitric oxide mediated signal transductionIDAbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008035High-density lipoprotein particle bindingIEAmolecular_function
GO:0008289Lipid bindingIDAmolecular_function
GO:0009897External side of plasma membraneIEAcellular_component
GO:0009986Cell surfaceIDA ISScellular_component
GO:0010744Positive regulation of macrophage derived foam cell differentiationIEA IMPbiological_process
GO:0010886Positive regulation of cholesterol storageIEAbiological_process
GO:0015911Plasma membrane long-chain fatty acid transportIDAbiological_process
GO:0016020MembraneTAScellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0019915Lipid storageIEA IMPbiological_process
GO:0019934CGMP-mediated signalingIDAbiological_process
GO:0030168Platelet activationTASbiological_process
GO:0030169Low-density lipoprotein particle bindingIDA IEAmolecular_function
GO:0030194Positive regulation of blood coagulationIEAbiological_process
GO:0030301Cholesterol transportIEA ISSbiological_process
GO:0030666Endocytic vesicle membraneTAScellular_component
GO:0031092Platelet alpha granule membraneTAScellular_component
GO:0032735Positive regulation of interleukin-12 productionIEAbiological_process
GO:0032755Positive regulation of interleukin-6 productionIEAbiological_process
GO:0032760Positive regulation of tumor necrosis factor productionIEAbiological_process
GO:0034134Toll-like receptor 2 signaling pathwayTASbiological_process
GO:0034142Toll-like receptor 4 signaling pathwayTASbiological_process
GO:0034381Plasma lipoprotein particle clearanceISSbiological_process
GO:0034383Low-density lipoprotein particle clearanceIEA IMPbiological_process
GO:0035634Response to stilbenoidIEAbiological_process
GO:0038123Toll-like receptor TLR1:TLR2 signaling pathwayTASbiological_process
GO:0038124Toll-like receptor TLR6:TLR2 signaling pathwayTASbiological_process
GO:0042590Antigen processing and presentation of exogenous peptide antigen via MHC class ITASbiological_process
GO:0042953Lipoprotein transportIEA IMP TASbiological_process
GO:0042992Negative regulation of transcription factor import into nucleusIEAbiological_process
GO:0043123Positive regulation of I-kappaB kinase/NF-kappaB signalingIEAbiological_process
GO:0043277Apoptotic cell clearanceIEAbiological_process
GO:0043410Positive regulation of MAPK cascadeIEAbiological_process
GO:0044130Negative regulation of growth of symbiont in hostIEAbiological_process
GO:0044255Cellular lipid metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0044539Long-chain fatty acid importIDAbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0045121Membrane raftIEAcellular_component
GO:0045335Phagocytic vesicleTAScellular_component
GO:0050431Transforming growth factor beta bindingISSmolecular_function
GO:0050731Positive regulation of peptidyl-tyrosine phosphorylationIEAbiological_process
GO:0050830Defense response to Gram-positive bacteriumIEAbiological_process
GO:0055096Low-density lipoprotein particle mediated signalingIEAbiological_process
GO:0060100Positive regulation of phagocytosis, engulfmentIEAbiological_process
GO:0060907Positive regulation of macrophage cytokine productionIEAbiological_process
GO:0070053Thrombospondin receptor activityISSmolecular_function
GO:0070892Lipoteichoic acid receptor activityIEAmolecular_function
GO:0071221Cellular response to bacterial lipopeptideIEAbiological_process
GO:0071222Cellular response to lipopolysaccharideIEAbiological_process
GO:0071223Cellular response to lipoteichoic acidIEAbiological_process
GO:0071447Cellular response to hydroperoxideIEAbiological_process
GO:0071813Lipoprotein particle bindingIDAmolecular_function
GO:2000121Regulation of removal of superoxide radicalsIEAbiological_process
GO:2000334Positive regulation of blood microparticle formationIEAbiological_process
GO:2000379Positive regulation of reactive oxygen species metabolic processIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00141709660.92640965770.10108238481.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.3894845839
GSE13712_SHEARUp0.0972516545
GSE13712_STATICDown-0.5690814513
GSE19018Up0.0768908356
GSE19899_A1Up0.1220949295
GSE19899_A2Up1.6920541809
PubMed_21979375_A1Up1.4172813158
PubMed_21979375_A2Up1.8053474014
GSE35957Up1.6478876325
GSE36640Up1.4322422100
GSE54402Up1.3144084585
GSE9593Down-0.6882647288
GSE43922Up1.5190854072
GSE24585Up0.2156769659
GSE37065Up0.1964770371
GSE28863_A1Down-0.3928396666
GSE28863_A2Up0.6725340253
GSE28863_A3Down-0.0038684533
GSE28863_A4Up0.0178005750
GSE48662Up0.1577377261

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT018933MicroarrayFunctional MTI (Weak)18185580
hsa-miR-155-5pMIMAT0000646MIRT021050Proteomics;OtherFunctional MTI (Weak)20584899
hsa-miR-26b-5pMIMAT0000083MIRT030109MicroarrayFunctional MTI (Weak)19088304
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 7 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

23119050Induction of CD36 and thrombospondin-1 in macrophages by hypoxia-inducible factor 1 and its relevance in the inflammatory process
23119050We aimed to analyse the role of p38-MAPK and HIF-1 in the transcriptional regulation of CD36, a class B scavenger receptor, and its ligand thrombospondin (TSP-1) in macrophages and to evaluate the involvement of this pathway in phagocytosis of apoptotic neutrophils
23119050We have also assessed HIF-1alpha, p38-MAPK and CD36 immunostaining in the mucosa of patients with inflammatory bowel disease
23119050Results show that hypoxia increases neutrophil phagocytosis by macrophages and induces the expression of CD36 and TSP-1
23119050Addition of a p38-MAPK inhibitor significantly reduced the increase in CD36 and TSP-1 expression provoked by hypoxia and decreased HIF-1alpha stabilization in macrophages
23119050Transient transfection of macrophages with a miHIF-1alpha-targeting vector blocked the increase in mRNA expression of CD36 and TSP-1 during hypoxia and reduced phagocytosis, thus highlighting a role for the transcriptional activity of HIF-1
23119050CD36 and TSP-1 were necessary for the phagocytosis of neutrophils induced by hypoxic macrophages, since functional blockade of these proteins undermined this process
23119050Immunohistochemical studies revealed CD36, HIF-1alpha and p38-MAPK expression in the mucosa of patients with inflammatory bowel disease
23119050A positive and significant correlation between HIF-1alpha and CD36 expression and CD36 and p38-MAPK expression was observed in cells of the lamina propria of the damaged mucosa
23119050Our results demonstrate a HIF-1-dependent up-regulation of CD36 and TSP-1 that mediates the increased phagocytosis of neutrophils by macrophages during hypoxia
23119050Moreover, they suggest that CD36 expression in the damaged mucosa of patients with inflammatory bowel disease depends on p38-MAPK and HIF-1 activity
19064796CD36 is a well-recognized integral microglia/macrophage cell membrane protein known to mediate phagocytosis of damaged, apoptotic, or senescent cells, including erythrocytes
19064796CD36 and catalase expression are regulated by peroxisome proliferator activated receptor-gamma agonists (eg, rosiglitazone)
19064796We demonstrate that peroxisome proliferator activated receptor-gamma agonist-induced upregulation of CD36 in macrophages enhances the ability of microglia to phagocytose red blood cells (in vitro assay), helps to improve hematoma resolution, and reduces ICH-induced deficit in a mouse model of ICH
18220826Previous experiments showed the involvement of phosphatidylserine and CD36 in the recognition of effete cell
17407326Conformation of an endogenous ligand in a membrane bilayer for the macrophage scavenger receptor CD36
17407326A structurally conserved family of oxidized phospholipids that serve as endogenous high-affinity ligands for the macrophage scavenger receptor CD36 (oxPC(CD36)) was recently identified
17407326The molecular model reveals a unique conformation for oxPC(CD36) within bilayers whereby the distal end of the sn-2 acyl chain harboring the structurally conserved CD36 recognition motif protrudes into the aqueous phase
17407326The remarkable conformation elucidated for oxPC(CD36) produces a surface accessible phagocytic "eat me signal" to facilitate senescent cell and oxidized lipoprotein recognition by the scavenger receptor CD36 as part of its immune surveillance function
10709907PS-liposome and ox-LDL bind to different sites of the immunodominant domain (#155-183) of CD36: a study with GS95, a new anti-CD36 monoclonal antibody
10709907CD36, a multifunctional adhesive receptor on a variety of cells such as monocytes and platelets, has been implicated in clearance of modified LDL and in the removal of apoptotic or senescent cells
10709907We determined the binding site of phosphatidylserine (PS)-liposome on CD36 by flow cytometric analysis of competitive bindings between phospholipid-liposomes or synthetic CD36 peptides and FITC-labeled anti-CD36 antibodies (GS95, OKM5, and FA6-152)
10709907The epitope of GS95 was mapped to the amino acid sequence #162-183 of CD36 that was partially overlapped with, but distinct from, #155-183, which has been reported as the epitopes of two commercially available antibodies, OKM5 and FA6-152
10709907Oxidized-LDL dose-dependently inhibited bindings of both GS95 and OKM5 antibodies to platelet CD36, while PS-liposome inhibited the binding of GS95 but not OKM5 or FA6-152
10709907These results indicate that the binding site of PS-liposome on platelet CD36 is not identical to that of oxidized-LDL and may be located in the amino acid sequence #162-183
8780395Mediation by alpha v beta 3/CD36/thrombospondin recognition mechanism and lack of phlogistic response
8780395Ingestion of apoptotic neutrophils by human monocyte-derived macrophages (M phi s) was found to be mediated by adhesive interactions between thrombospondin and the M phi alpha v beta 3 vitronectin receptor integrin and M phi CD36
8780395In this study, we found that M phi ingestion of apoptotic eosinophils was specifically inhibited by monoclonal antibodies to M phi alpha v beta 3, CD36, and thrombospondin and by other inhibitors of this recognition mechanism including RGD peptide and amino sugars
8780395The data indicate that the nonphlogistic alpha v beta 3/CD36/thrombospondin macrophage recognition mechanism is available for clearance of intact senescent eosinophils undergoing apoptosis
7541795The class B scavenger receptors SR-BI and CD36 are receptors for anionic phospholipids
7541795Using both direct binding and ligand competition assays in transfected cells, we have found that two class B scavenger receptors, SR-BI and CD36, can tightly bind PS and phosphatidylinositol (PI)-containing liposomes (Kd for PS liposome binding to SR-BI is approximately 15 micrograms phospholipid/ml or 0
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