HCSGD entry for AKAP6

1. General information

Official gene symbolAKAP6
Entrez ID9472
Gene full nameA kinase (PRKA) anchor protein 6
Other gene symbolsADAP100 ADAP6 AKAP100 PRKA6 mAKAP
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001508Action potentialICbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005635Nuclear envelopeIDAcellular_component
GO:0005737CytoplasmISScellular_component
GO:0005901CaveolaISScellular_component
GO:0006605Protein targetingNASbiological_process
GO:0008179Adenylate cyclase bindingISSmolecular_function
GO:0010738Regulation of protein kinase A signalingISSbiological_process
GO:0010880Regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulumICbiological_process
GO:0014701Junctional sarcoplasmic reticulum membraneISScellular_component
GO:0014704Intercalated discISScellular_component
GO:0016529Sarcoplasmic reticulumIDAcellular_component
GO:0019933CAMP-mediated signalingNASbiological_process
GO:0030307Positive regulation of cell growthISSbiological_process
GO:0030315T-tubuleISScellular_component
GO:0030818Negative regulation of cAMP biosynthetic processISSbiological_process
GO:0031965Nuclear membraneIEAcellular_component
GO:0032514Positive regulation of protein phosphatase type 2B activityISSbiological_process
GO:0032947Protein complex scaffoldISSmolecular_function
GO:0034237Protein kinase A regulatory subunit bindingISSmolecular_function
GO:0034704Calcium channel complexIDAcellular_component
GO:0043495Protein anchorISSmolecular_function
GO:0044325Ion channel bindingIPImolecular_function
GO:0048471Perinuclear region of cytoplasmIDA IEA ISScellular_component
GO:0051018Protein kinase A bindingNAS TASmolecular_function
GO:0051281Positive regulation of release of sequestered calcium ion into cytosolISSbiological_process
GO:0051533Positive regulation of NFAT protein import into nucleusISSbiological_process
GO:0060306Regulation of membrane repolarizationIDAbiological_process
GO:0060316Positive regulation of ryanodine-sensitive calcium-release channel activityISSbiological_process
GO:0061051Positive regulation of cell growth involved in cardiac muscle cell developmentISSbiological_process
GO:0070886Positive regulation of calcineurin-NFAT signaling cascadeISSbiological_process
GO:0071320Cellular response to cAMPIDAbiological_process
GO:0071345Cellular response to cytokine stimulusISSbiological_process
GO:1901381Positive regulation of potassium ion transmembrane transportIDAbiological_process
GO:1902261Positive regulation of delayed rectifier potassium channel activityIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.11413298510.35902149990.69516501621.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0705031717
GSE13712_SHEARUp0.0252426599
GSE13712_STATICUp0.0122990250
GSE19018Up0.0317678961
GSE19899_A1Up0.0341154584
GSE19899_A2Up0.0655008273
PubMed_21979375_A1Up0.1765568381
PubMed_21979375_A2Up0.0896139639
GSE35957Up0.4107829620
GSE36640Up0.6162828321
GSE54402Up0.2865655108
GSE9593Up0.1792320969
GSE43922Up0.7212123226
GSE24585Up0.3595998059
GSE37065Up0.7782882668
GSE28863_A1Down-0.4815448855
GSE28863_A2Down-0.2843893159
GSE28863_A3Down-1.4742664284
GSE28863_A4Down-0.0300993524
GSE48662Up0.1333376050

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.