HCSGD entry for EIF4E2
1. General information
| Official gene symbol | EIF4E2 |
|---|---|
| Entrez ID | 9470 |
| Gene full name | eukaryotic translation initiation factor 4E family member 2 |
| Other gene symbols | 4E-LP 4EHP EIF4EL3 IF4e |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000339 | RNA cap binding | TAS | molecular_function |
| GO:0001701 | In utero embryonic development | IEA | biological_process |
| GO:0003743 | Translation initiation factor activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005845 | MRNA cap binding complex | IDA | cellular_component |
| GO:0008135 | Translation factor activity, nucleic acid binding | TAS | molecular_function |
| GO:0017148 | Negative regulation of translation | IMP | biological_process |
| GO:0019221 | Cytokine-mediated signaling pathway | TAS | biological_process |
| GO:0031625 | Ubiquitin protein ligase binding | IPI | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9628219065 | 0.2536307245 | 0.9999902473 | 0.9663454282 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2290359245 |
| GSE13712_SHEAR | Down | -0.0144717751 |
| GSE13712_STATIC | Up | 0.1257839753 |
| GSE19018 | Up | 0.1124058988 |
| GSE19899_A1 | Down | -0.0488331714 |
| GSE19899_A2 | Down | -0.1240449783 |
| PubMed_21979375_A1 | Up | 0.2517560942 |
| PubMed_21979375_A2 | Down | -0.0299248028 |
| GSE35957 | Down | -0.1924206624 |
| GSE36640 | Down | -0.1373350533 |
| GSE54402 | Up | 0.1057067999 |
| GSE9593 | Down | -0.1785820364 |
| GSE43922 | Up | 0.0076778774 |
| GSE24585 | Down | -0.2353028917 |
| GSE37065 | Down | -0.2260506827 |
| GSE28863_A1 | Down | -0.0287495333 |
| GSE28863_A2 | Up | 0.0045384715 |
| GSE28863_A3 | Down | -0.1631437828 |
| GSE28863_A4 | Down | -0.0721321188 |
| GSE48662 | Down | -0.1811261654 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-155-5p | MIMAT0000646 | MIRT020573 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-98-5p | MIMAT0000096 | MIRT027566 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-181b-5p | MIMAT0000257 | MIRT047290 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
