HCSGD entry for AIM2
1. General information
| Official gene symbol | AIM2 |
|---|---|
| Entrez ID | 9447 |
| Gene full name | absent in melanoma 2 |
| Other gene symbols | PYHIN4 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002218 | Activation of innate immune response | IDA IEA | biological_process |
| GO:0002230 | Positive regulation of defense response to virus by host | IEA ISS | biological_process |
| GO:0003690 | Double-stranded DNA binding | IDA IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA IEA | cellular_component |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006915 | Apoptotic process | IEA | biological_process |
| GO:0006954 | Inflammatory response | IEA | biological_process |
| GO:0006955 | Immune response | TAS | biological_process |
| GO:0032088 | Negative regulation of NF-kappaB transcription factor activity | IDA | biological_process |
| GO:0032461 | Positive regulation of protein oligomerization | IDA | biological_process |
| GO:0032731 | Positive regulation of interleukin-1 beta production | IDA IEA | biological_process |
| GO:0033209 | Tumor necrosis factor-mediated signaling pathway | IDA | biological_process |
| GO:0035458 | Cellular response to interferon-beta | IEA | biological_process |
| GO:0035690 | Cellular response to drug | IDA | biological_process |
| GO:0035872 | Nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway | TAS | biological_process |
| GO:0042802 | Identical protein binding | IEA IPI | molecular_function |
| GO:0045087 | Innate immune response | TAS | biological_process |
| GO:0050702 | Interleukin-1 beta secretion | IMP | biological_process |
| GO:0050718 | Positive regulation of interleukin-1 beta secretion | IDA | biological_process |
| GO:0051092 | Positive regulation of NF-kappaB transcription factor activity | IDA | biological_process |
| GO:0070269 | Pyroptosis | IDA IEA | biological_process |
| GO:0097169 | AIM2 inflammasome complex | IDA IEA | cellular_component |
| GO:2001056 | Positive regulation of cysteine-type endopeptidase activity | IDA IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5901100832 | 0.5547792067 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0059945858 |
| GSE13712_SHEAR | Up | 0.0738494085 |
| GSE13712_STATIC | Up | 0.0134437449 |
| GSE19018 | Up | 0.0845438316 |
| GSE19899_A1 | Up | 0.2322635327 |
| GSE19899_A2 | Up | 0.0028269740 |
| PubMed_21979375_A1 | Up | 0.0879286437 |
| PubMed_21979375_A2 | Up | 0.1121764355 |
| GSE35957 | Up | 0.1189065816 |
| GSE36640 | Down | -0.0044045902 |
| GSE54402 | Up | 0.0218356564 |
| GSE9593 | Down | -0.3808542800 |
| GSE43922 | Up | 0.0120147115 |
| GSE24585 | Down | -0.2191425093 |
| GSE37065 | Up | 0.5613805044 |
| GSE28863_A1 | Down | -0.1976993090 |
| GSE28863_A2 | Down | -0.1247809804 |
| GSE28863_A3 | Up | 0.1226047147 |
| GSE28863_A4 | Up | 0.1008066178 |
| GSE48662 | Down | -0.1396798192 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT023788 | Microarray | Functional MTI (Weak) | 18668037 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23864729 | AIM2, an IFN-inducible cytosolic DNA sensor, in the development of benign prostate hyperplasia and prostate cancer |
| 23864729 | Recent studies have indicated that the IFN-inducible AIM2 protein is a cytosolic DNA sensor in macrophages and keratinocytes |
| 23864729 | Activation of the AIM2 inflammasome cleaves pro-interleukin (IL)-1beta and pro-IL-18 and promotes the secretion of IL-1beta and IL-18 proinflammatory cytokines |
| 23864729 | It was determined that IFNs (alpha, beta, or gamma) induced AIM2 expression in human prostate epithelial cells and cytosolic DNA activated the AIM2 inflammasome |
| 23864729 | Steady-state levels of the AIM2 mRNA were higher in BPH than in normal prostate tissue |
| 23864729 | However, the levels of AIM2 mRNA were significantly lower in clinical tumor specimens |
| 23864729 | Accordingly, constitutive levels of AIM2 mRNA and protein were lower in a subset of prostate cancer cells as compared with BPH cells |
| 23864729 | IMPLICATIONS: The AIM2 inflammasome has a fundamental role in the generation of human prostatic diseases |
| 21471287 | Differential roles for the interferon-inducible IFI16 and AIM2 innate immune sensors for cytosolic DNA in cellular senescence of human fibroblasts |
| 21471287 | The IFN-inducible IFI16 and AIM2 proteins act as innate immune sensors for cytosolic double-stranded DNA (dsDNA) |
| 21471287 | On sensing dsDNA, the IFI16 protein induces the expression of IFN-beta whereas the AIM2 protein forms an inflammasome, which promotes the secretion of IL-1beta |
| 21471287 | Given that the knockdown of IFI16 expression in human diploid fibroblasts (HDF) delays the onset of cellular senescence, we investigated the potential roles for the IFI16 and AIM2 proteins in cellular senescence |
| 21471287 | In contrast, increased levels of the AIM2 protein in the senescent (vs |
| 21471287 | The knockdown of type I IFN-alpha receptor subunit, which reduced the basal levels of the IFI16 but not of the AIM2, protein delayed the onset of cellular senescence |
| 21471287 | Accordingly, increased constitutive levels of IFI16 and AIM2 proteins in ataxia telangiectasia mutated (ATM) HDFs were associated with the activation of the IFN signaling and increased levels of IL-1beta |
| 21471287 | The IFN-beta treatment of the young HDFs, which induced the expression of IFI16 and AIM2 proteins, activated a DNA damage response and also increased basal levels of IL-1beta |
| 21471287 | Interestingly, the knockdown of AIM2 expression in HDFs increased the basal levels of IFI16 protein and activated the IFN signaling |
| 21471287 | Collectively, our observations show differential roles for the IFI16 and AIM2 proteins in cellular senescence and associated secretory phenotype |
| 17981573 | The family includes structurally and functionally-related mouse (for example, p202, p203, and p204 proteins) and human (for example, MNDA, AIM2, and IFIX) proteins |
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