HCSGD entry for TNFRSF8

1. General information

Official gene symbolTNFRSF8
Entrez ID943
Gene full nametumor necrosis factor receptor superfamily, member 8
Other gene symbolsCD30 D1S166E Ki-1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004888Transmembrane signaling receptor activityIEA TASmolecular_function
GO:0005031Tumor necrosis factor-activated receptor activityRCAmolecular_function
GO:0005737CytoplasmIEAcellular_component
GO:0005886Plasma membraneIEAcellular_component
GO:0007165Signal transductionTASbiological_process
GO:0008285Negative regulation of cell proliferationTASbiological_process
GO:0012501Programmed cell deathRCAbiological_process
GO:0016021Integral component of membraneIEAcellular_component
GO:0033209Tumor necrosis factor-mediated signaling pathwayRCAbiological_process
GO:0042535Positive regulation of tumor necrosis factor biosynthetic processIDAbiological_process
GO:0043065Positive regulation of apoptotic processIDAbiological_process
GO:0045556Positive regulation of TRAIL biosynthetic processIDAbiological_process
GO:0071260Cellular response to mechanical stimulusIEPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.43879748110.86988344670.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0132541034
GSE13712_SHEARUp0.0522954581
GSE13712_STATICUp0.1327814166
GSE19018Up0.1999334794
GSE19899_A1Down-0.0054305219
GSE19899_A2Down-0.0961113978
PubMed_21979375_A1Up0.0210592217
PubMed_21979375_A2Up0.0795405065
GSE35957Up0.1234611984
GSE36640Up0.0519935511
GSE54402Down-0.0657670299
GSE9593Down-0.0048466492
GSE43922Up0.1993767869
GSE24585Down-0.0315695505
GSE37065Down-0.0810299672
GSE28863_A1Down-0.0244282000
GSE28863_A2Up0.0814234996
GSE28863_A3Up0.2676692705
GSE28863_A4Up0.1741191179
GSE48662Down-0.1023660358

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Brentuximab vedotinDB08870 -

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26498461Induction of IkappaB-zeta by Epstein-Barr virus latent membrane protein-1 and CD30
26498461Epstein-Barr virus (EBV) latent membrane protein-1 (LMP-1) and ligand-independent signaling by overexpressed CD30 are known to cause permanent activation of NF-kappaB in lymphomas
26498461Expression of LMP-1 and CD30 increased IkappaB-zeta expression at the transcriptional level
26498461Interestingly, IkappaB-zeta inhibited NF-kappaB activation by LMP-1 and CD30
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