HCSGD entry for ABCG2
1. General information
| Official gene symbol | ABCG2 |
|---|---|
| Entrez ID | 9429 |
| Gene full name | ATP-binding cassette, sub-family G (WHITE), member 2 |
| Other gene symbols | ABC15 ABCP BCRP BCRP1 BMDP CD338 CDw338 EST157481 GOUT1 MRX MXR MXR1 UAQTL1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005215 | Transporter activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0006200 | ATP catabolic process | TAS | biological_process |
| GO:0006810 | Transport | TAS | biological_process |
| GO:0006855 | Drug transmembrane transport | TAS | biological_process |
| GO:0006879 | Cellular iron ion homeostasis | TAS | biological_process |
| GO:0008559 | Xenobiotic-transporting ATPase activity | TAS | molecular_function |
| GO:0015232 | Heme transporter activity | TAS | molecular_function |
| GO:0015886 | Heme transport | TAS | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0031966 | Mitochondrial membrane | IEA | cellular_component |
| GO:0042493 | Response to drug | TAS | biological_process |
| GO:0042626 | ATPase activity, coupled to transmembrane movement of substances | TAS | molecular_function |
| GO:0042803 | Protein homodimerization activity | IDA | molecular_function |
| GO:0042908 | Xenobiotic transport | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046415 | Urate metabolic process | IMP | biological_process |
| GO:0051181 | Cofactor transport | TAS | biological_process |
| GO:0055085 | Transmembrane transport | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0358210250 | 0.1634011284 | 0.4312288848 | 0.7813647048 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.8983160927 |
| GSE13712_SHEAR | Down | -2.0895756335 |
| GSE13712_STATIC | Down | -0.2828101480 |
| GSE19018 | Down | -0.5334470592 |
| GSE19899_A1 | Down | -0.0732104057 |
| GSE19899_A2 | Up | 0.4574376178 |
| PubMed_21979375_A1 | Up | 0.5971896928 |
| PubMed_21979375_A2 | Up | 1.1330880853 |
| GSE35957 | Down | -0.5672811260 |
| GSE36640 | Up | 0.4211017660 |
| GSE54402 | Up | 0.6065123162 |
| GSE9593 | Up | 0.0905666643 |
| GSE43922 | Up | 0.8931509929 |
| GSE24585 | Down | -1.1489615482 |
| GSE37065 | Up | 0.0049349354 |
| GSE28863_A1 | Down | -0.0181293039 |
| GSE28863_A2 | Up | 0.3400679107 |
| GSE28863_A3 | Down | -0.0920203915 |
| GSE28863_A4 | Up | 0.0261095846 |
| GSE48662 | Down | -0.1103601839 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Biricodar dicitrate | DB04851 | - |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-328-3p | MIMAT0000752 | MIRT000081 | Luciferase reporter assay//qRT-PCR//Western blot//Reporter assay;Western blot;qRT-PCR;Other | Functional MTI | 19270061 |
| hsa-miR-519c-3p | MIMAT0002832 | MIRT000998 | Western blot//Luciferase reporter assay//qRT-PCR | Functional MTI | 18573883 |
| hsa-miR-519c-3p | MIMAT0002832 | MIRT000998 | Luciferase reporter assay | Functional MTI | 19825807 |
| hsa-miR-520h | MIMAT0002867 | MIRT001952 | Luciferase reporter assay | Functional MTI | 19825807 |
| hsa-miR-520h | MIMAT0002867 | MIRT001952 | qRT-PCR//Western blot | Functional MTI | 20628378 |
| hsa-miR-520h | MIMAT0002867 | MIRT001952 | Microarray | Functional MTI (Weak) | 18189265 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT004129 | Microarray | Functional MTI (Weak) | 16822819 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029929 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-10a-5p | MIMAT0000253 | MIRT047731 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-520h | MIMAT0002867 | NA | hsa-miR-520h | 18189265 | |||
| hsa-miR-519c-3p | MIMAT0002832 | 1 | hsa-miR-519c-3p | 18573883 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27336873 | The expressions of lens progenitor cell-related markers Sox2, Abcg2, and Ki67 were first examined in human lens epithelial cells (HLECs) in situ |
| 27336873 | Ki67, Sox2, and Abcg2 HLECs in lens capsules were clearly more abundant in young people than in patients older than 50 years, and they were almost absent in patients older than 60 years |
| 22564971 | The characteristics of the proliferating cells were examined by immunofluorescent staining using antibodies against deltaNP63, ABCG2 and Keratin 3/12 |
| 22564971 | Immunofluorescent staining suggested that the pluripotin treatment resulted in higher positive staining for the limbal stem cell markers (deltaNP63 and ABCG2) and down-regulated of differentiated corneal epithelial cell marker (Keratin 3/12) |
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