HCSGD entry for DDX23
1. General information
| Official gene symbol | DDX23 |
|---|---|
| Entrez ID | 9416 |
| Gene full name | DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 |
| Other gene symbols | PRPF28 U5-100K U5-100KD prp28 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000354 | Cis assembly of pre-catalytic spliceosome | IC | biological_process |
| GO:0000375 | RNA splicing, via transesterification reactions | TAS | biological_process |
| GO:0000398 | MRNA splicing, via spliceosome | IC TAS | biological_process |
| GO:0003676 | Nucleic acid binding | IEA | molecular_function |
| GO:0004004 | ATP-dependent RNA helicase activity | TAS | molecular_function |
| GO:0004386 | Helicase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005682 | U5 snRNP | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0006200 | ATP catabolic process | TAS | biological_process |
| GO:0008026 | ATP-dependent helicase activity | IDA IEA | molecular_function |
| GO:0008380 | RNA splicing | TAS | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0071013 | Catalytic step 2 spliceosome | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0184168497 | 0.9586297215 | 0.3321217659 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.4838689803 |
| GSE13712_SHEAR | Down | -0.0031262935 |
| GSE13712_STATIC | Up | 0.0028460650 |
| GSE19018 | Down | -0.1538705043 |
| GSE19899_A1 | Up | 0.5229703170 |
| GSE19899_A2 | Up | 0.5625944804 |
| PubMed_21979375_A1 | Up | 1.4244103437 |
| PubMed_21979375_A2 | Up | 1.4095800896 |
| GSE35957 | Down | -0.4716131711 |
| GSE36640 | Down | -0.1787244090 |
| GSE54402 | Up | 0.2992265630 |
| GSE9593 | Down | -0.0913187287 |
| GSE43922 | Up | 0.4449187461 |
| GSE24585 | Down | -0.1316634030 |
| GSE37065 | Up | 0.0005287967 |
| GSE28863_A1 | Up | 0.0697396049 |
| GSE28863_A2 | Up | 0.1415315771 |
| GSE28863_A3 | Up | 0.5060533496 |
| GSE28863_A4 | Up | 0.2697013103 |
| GSE48662 | Down | -0.0897503714 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1229-3p | MIMAT0005584 | MIRT036357 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-744-5p | MIMAT0004945 | MIRT037450 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039941 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-361-5p | MIMAT0000703 | MIRT044059 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-106b-5p | MIMAT0000680 | MIRT044348 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-149-5p | MIMAT0000450 | MIRT045430 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT048936 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-25-3p | MIMAT0000081 | MIRT050352 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
