HCSGD entry for FADS2
1. General information
| Official gene symbol | FADS2 |
|---|---|
| Entrez ID | 9415 |
| Gene full name | fatty acid desaturase 2 |
| Other gene symbols | D6D DES6 FADSD6 LLCDL2 SLL0262 TU13 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004768 | Stearoyl-CoA 9-desaturase activity | IEA | molecular_function |
| GO:0005506 | Iron ion binding | IEA | molecular_function |
| GO:0005789 | Endoplasmic reticulum membrane | TAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | TAS | cellular_component |
| GO:0006629 | Lipid metabolic process | IEA | biological_process |
| GO:0006633 | Fatty acid biosynthetic process | IEA | biological_process |
| GO:0006636 | Unsaturated fatty acid biosynthetic process | IEA | biological_process |
| GO:0016020 | Membrane | TAS | cellular_component |
| GO:0016717 | Oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water | IEA | molecular_function |
| GO:0020037 | Heme binding | IEA | molecular_function |
| GO:0033559 | Unsaturated fatty acid metabolic process | TAS | biological_process |
| GO:0036109 | Alpha-linolenic acid metabolic process | TAS | biological_process |
| GO:0043651 | Linoleic acid metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9071859200 | 0.0299881046 | 0.9999902473 | 0.3270237780 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0411653658 |
| GSE13712_SHEAR | Down | -1.5078315666 |
| GSE13712_STATIC | Down | -1.0468797472 |
| GSE19018 | Down | -0.2139327335 |
| GSE19899_A1 | Down | -0.1477660774 |
| GSE19899_A2 | Up | 0.0586978956 |
| PubMed_21979375_A1 | Down | -1.2763727609 |
| PubMed_21979375_A2 | Down | -0.0150087074 |
| GSE35957 | Down | -0.3916022771 |
| GSE36640 | Down | -0.1525880758 |
| GSE54402 | Down | -0.3931725517 |
| GSE9593 | Down | -0.2377115060 |
| GSE43922 | Down | -0.4967084280 |
| GSE24585 | Up | 0.1799459285 |
| GSE37065 | Up | 0.2813291636 |
| GSE28863_A1 | Down | -0.0958698117 |
| GSE28863_A2 | Up | 0.3354608413 |
| GSE28863_A3 | Down | -0.1895967647 |
| GSE28863_A4 | Up | 0.1653789865 |
| GSE48662 | Up | 0.2747153806 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-let-7b-5p | MIMAT0000063 | MIRT001634 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT001634 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT017360 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029144 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-18a-3p | MIMAT0002891 | MIRT040802 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-500a-3p | MIMAT0002871 | MIRT041155 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-423-3p | MIMAT0001340 | MIRT042511 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-3p | MIMAT0000762 | MIRT042871 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
