HCSGD entry for ACVRL1

1. General information

Official gene symbolACVRL1
Entrez ID94
Gene full nameactivin A receptor type II-like 1
Other gene symbolsACVRLK1 ALK-1 ALK1 HHT HHT2 ORW2 SKR3 TSR-I
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001525AngiogenesisIEA IMPbiological_process
GO:0001701In utero embryonic developmentIEAbiological_process
GO:0001936Regulation of endothelial cell proliferationTASbiological_process
GO:0001937Negative regulation of endothelial cell proliferationIEAbiological_process
GO:0001938Positive regulation of endothelial cell proliferationIEAbiological_process
GO:0001946LymphangiogenesisIEA ISSbiological_process
GO:0001955Blood vessel maturationTASbiological_process
GO:0001974Blood vessel remodelingIEA ISSbiological_process
GO:0002043Blood vessel endothelial cell proliferation involved in sprouting angiogenesisTASbiological_process
GO:0004672Protein kinase activityIEAmolecular_function
GO:0004674Protein serine/threonine kinase activityIDA IEAmolecular_function
GO:0004675Transmembrane receptor protein serine/threonine kinase activityRCAmolecular_function
GO:0004702Receptor signaling protein serine/threonine kinase activityIEAmolecular_function
GO:0005024Transforming growth factor beta-activated receptor activityIDA IEAmolecular_function
GO:0005025Transforming growth factor beta receptor activity, type IIDA IEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIDA IEAmolecular_function
GO:0005887Integral component of plasma membraneIDAcellular_component
GO:0006275Regulation of DNA replicationTASbiological_process
GO:0006355Regulation of transcription, DNA-templatedIMPbiological_process
GO:0006468Protein phosphorylationIDAbiological_process
GO:0007162Negative regulation of cell adhesionIMPbiological_process
GO:0007165Signal transductionIDAbiological_process
GO:0007179Transforming growth factor beta receptor signaling pathwayIDA IEAbiological_process
GO:0008015Blood circulationIMPbiological_process
GO:0008217Regulation of blood pressureIMPbiological_process
GO:0008285Negative regulation of cell proliferationIMPbiological_process
GO:0009986Cell surfaceIDAcellular_component
GO:0010596Negative regulation of endothelial cell migrationIDAbiological_process
GO:0010862Positive regulation of pathway-restricted SMAD protein phosphorylationIMPbiological_process
GO:0016020MembraneIEAcellular_component
GO:0016361Activin receptor activity, type IIDA TASmolecular_function
GO:0019901Protein kinase bindingIPImolecular_function
GO:0030308Negative regulation of cell growthIDAbiological_process
GO:0030336Negative regulation of cell migrationIMPbiological_process
GO:0030425DendriteIEAcellular_component
GO:0030509BMP signaling pathwayIEA IMPbiological_process
GO:0030513Positive regulation of BMP signaling pathwayIDA IEAbiological_process
GO:0032332Positive regulation of chondrocyte differentiationTASbiological_process
GO:0032924Activin receptor signaling pathwayIDAbiological_process
GO:0035313Wound healing, spreading of epidermal cellsIMPbiological_process
GO:0043025Neuronal cell bodyIEAcellular_component
GO:0043535Regulation of blood vessel endothelial cell migrationTASbiological_process
GO:0043537Negative regulation of blood vessel endothelial cell migrationIMPbiological_process
GO:0045602Negative regulation of endothelial cell differentiationIEAbiological_process
GO:0045603Positive regulation of endothelial cell differentiationIEAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDA IEAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0046332SMAD bindingIDA IEAmolecular_function
GO:0046872Metal ion bindingIEAmolecular_function
GO:0048185Activin bindingIDAmolecular_function
GO:0050431Transforming growth factor beta bindingIPImolecular_function
GO:0051291Protein heterooligomerizationIEAbiological_process
GO:0051895Negative regulation of focal adhesion assemblyIMPbiological_process
GO:0060836Lymphatic endothelial cell differentiationIMPbiological_process
GO:0060840Artery developmentIEA ISSbiological_process
GO:0060841Venous blood vessel developmentIEA ISSbiological_process
GO:0061154Endothelial tube morphogenesisIMPbiological_process
GO:0061298Retina vasculature development in camera-type eyeIEA ISSbiological_process
GO:0071560Cellular response to transforming growth factor beta stimulusIDAbiological_process
GO:0071773Cellular response to BMP stimulusIMPbiological_process
GO:2000279Negative regulation of DNA biosynthetic processIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00387595460.86677143350.16724426231.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1104091468
GSE13712_SHEARDown-0.0753052978
GSE13712_STATICDown-0.0642185720
GSE19018Down-0.3011402985
GSE19899_A1Up0.7521664293
GSE19899_A2Up3.2002325520
PubMed_21979375_A1Up1.6339531769
PubMed_21979375_A2Up3.2499586785
GSE35957Up0.4132260351
GSE36640Down-0.0297264073
GSE54402Up0.0360763018
GSE9593Down-0.0719887303
GSE43922Up1.7733762831
GSE24585Up0.0434038847
GSE37065Up0.2338755216
GSE28863_A1Up0.6524063313
GSE28863_A2Up0.4764964940
GSE28863_A3Down-0.5910506469
GSE28863_A4Down-0.0012483414
GSE48662Up0.1461138093

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Adenosine triphosphateDB00171 NUTR00017 | EXPT00007

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24777481Endoglin plays a crucial role in pathophysiological processes such as hereditary hemorrhagic telangiectasia (HHT), preeclampsia and cancer
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