HCSGD entry for LIPG
1. General information
| Official gene symbol | LIPG |
|---|---|
| Entrez ID | 9388 |
| Gene full name | lipase, endothelial |
| Other gene symbols | EDL EL PRO719 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004465 | Lipoprotein lipase activity | IEA | molecular_function |
| GO:0004620 | Phospholipase activity | IDA | molecular_function |
| GO:0005576 | Extracellular region | IEA | cellular_component |
| GO:0005615 | Extracellular space | IDA IEA | cellular_component |
| GO:0006629 | Lipid metabolic process | IEA TAS | biological_process |
| GO:0007584 | Response to nutrient | IEA | biological_process |
| GO:0008201 | Heparin binding | IEA | molecular_function |
| GO:0008283 | Cell proliferation | IEA | biological_process |
| GO:0008970 | Phosphatidylcholine 1-acylhydrolase activity | IDA | molecular_function |
| GO:0009395 | Phospholipid catabolic process | NAS | biological_process |
| GO:0010983 | Positive regulation of high-density lipoprotein particle clearance | IMP | biological_process |
| GO:0032376 | Positive regulation of cholesterol transport | IDA | biological_process |
| GO:0034375 | High-density lipoprotein particle remodeling | IMP | biological_process |
| GO:0042632 | Cholesterol homeostasis | IMP | biological_process |
| GO:0043691 | Reverse cholesterol transport | IMP | biological_process |
| GO:0050746 | Regulation of lipoprotein metabolic process | IEA | biological_process |
| GO:0055091 | Phospholipid homeostasis | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0005953801 | 0.7125470575 | 0.0696488889 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 2.4234029695 |
| GSE13712_SHEAR | Down | -0.8791799237 |
| GSE13712_STATIC | Down | -0.1363936375 |
| GSE19018 | Down | -0.4357863027 |
| GSE19899_A1 | Up | 0.3573123866 |
| GSE19899_A2 | Up | 4.8891880845 |
| PubMed_21979375_A1 | Up | 0.9581940394 |
| PubMed_21979375_A2 | Up | 3.9063371337 |
| GSE35957 | Up | 0.0353620989 |
| GSE36640 | Up | 0.3562722767 |
| GSE54402 | Up | 2.0775672886 |
| GSE9593 | Up | 0.2064240988 |
| GSE43922 | Up | 1.6346985284 |
| GSE24585 | Up | 0.1090471377 |
| GSE37065 | Up | 0.8387715189 |
| GSE28863_A1 | Down | -0.1195247491 |
| GSE28863_A2 | Down | -0.1098686524 |
| GSE28863_A3 | Up | 0.1521623845 |
| GSE28863_A4 | Up | 0.0668949811 |
| GSE48662 | Down | -0.0571940184 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017862 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25946838 | The mechanism of geroprotective effect of peptides AED and EDL was studied in ageing renal cell culture |
| 25946838 | It is shown that interaction of peptides AED and EDL with DNA is the cause of gene expression, encoded marker of ageing in renal cells |
| 22178194 | Affymetrix gene array data showed NeuT-induced alterations in the transcription of many enzymes involved in lipid metabolism, several of which (ACSL3, CHPT1, PLD1, LIPG, MGLL, LDL and NPC1) could be confirmed by quantitative realtime PCR |
| 20713685 | VAT-EC exhibited a marked angiogenic and inflammatory state with decreased expression of metabolism-related genes, including endothelial lipase, GPIHBP1, and PPAR gamma |
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