HCSGD entry for SLC9A3R1

1. General information

Official gene symbolSLC9A3R1
Entrez ID9368
Gene full namesolute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
Other gene symbolsEBP50 NHERF NHERF-1 NHERF1 NPHLOP2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001726RuffleIEAcellular_component
GO:0003096Renal sodium ion transportIEAbiological_process
GO:0005102Receptor bindingIPImolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005737CytoplasmIDA IEAcellular_component
GO:0005813CentrosomeIDAcellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0005902MicrovillusIDAcellular_component
GO:0006461Protein complex assemblyTASbiological_process
GO:0007191Adenylate cyclase-activating dopamine receptor signaling pathwayIEAbiological_process
GO:0008013Beta-catenin bindingIPImolecular_function
GO:0008285Negative regulation of cell proliferationIDA IMPbiological_process
GO:0010642Negative regulation of platelet-derived growth factor receptor signaling pathwayIEA ISSbiological_process
GO:0010766Negative regulation of sodium ion transportIEAbiological_process
GO:0012505Endomembrane systemIEAcellular_component
GO:0014067Negative regulation of phosphatidylinositol 3-kinase signalingIEA ISSbiological_process
GO:0015629Actin cytoskeletonTAScellular_component
GO:0016020MembraneIDAcellular_component
GO:0016055Wnt signaling pathwayIEAbiological_process
GO:0016324Apical plasma membraneIEAcellular_component
GO:0017081Chloride channel regulator activityIDAmolecular_function
GO:0019902Phosphatase bindingIEA IPImolecular_function
GO:0030033Microvillus assemblyIMPbiological_process
GO:0030036Actin cytoskeleton organizationIEAbiological_process
GO:0030165PDZ domain bindingIEA IPImolecular_function
GO:0030175FilopodiumIEAcellular_component
GO:0030336Negative regulation of cell migrationIEAbiological_process
GO:0030643Cellular phosphate ion homeostasisIEAbiological_process
GO:0031526Brush border membraneIEAcellular_component
GO:0031528Microvillus membraneIEA ISScellular_component
GO:0031698Beta-2 adrenergic receptor bindingIPImolecular_function
GO:0032403Protein complex bindingIEAmolecular_function
GO:0032415Regulation of sodium:hydrogen antiporter activityNASbiological_process
GO:0032416Negative regulation of sodium:hydrogen antiporter activityIEAbiological_process
GO:0032782Bile acid secretionIEA ISSbiological_process
GO:0032947Protein complex scaffoldIEAmolecular_function
GO:0034613Cellular protein localizationIEAbiological_process
GO:0034635Glutathione transportIEA ISSbiological_process
GO:0043231Intracellular membrane-bounded organelleIDAcellular_component
GO:0043621Protein self-associationIDAmolecular_function
GO:0044062Regulation of excretionIEAbiological_process
GO:0045121Membrane raftIEAcellular_component
GO:0045859Regulation of protein kinase activityIEA ISSbiological_process
GO:0050780Dopamine receptor bindingIEAmolecular_function
GO:0051898Negative regulation of protein kinase B signalingIEA IMPbiological_process
GO:0060158Phospholipase C-activating dopamine receptor signaling pathwayIEAbiological_process
GO:0070293Renal absorptionIEA ISSbiological_process
GO:0070373Negative regulation of ERK1 and ERK2 cascadeIDAbiological_process
GO:0070851Growth factor receptor bindingIPImolecular_function
GO:0071944Cell peripheryIDAcellular_component
GO:0097225Sperm midpieceIEA ISScellular_component
GO:0097291Renal phosphate ion absorptionIMPbiological_process
GO:2001244Positive regulation of intrinsic apoptotic signaling pathwayIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.44332837660.21450658030.99999024730.8940661441

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0494748931
GSE13712_SHEARUp0.2848246475
GSE13712_STATICUp0.3290525239
GSE19018Up0.0813083332
GSE19899_A1Down-0.2336178044
GSE19899_A2Up0.3713035489
PubMed_21979375_A1Down-0.0652933509
PubMed_21979375_A2Up0.1143542351
GSE35957Down-0.5240444755
GSE36640Down-0.8746351396
GSE54402Up0.0125660334
GSE9593Up0.0135391989
GSE43922Down-0.0750005421
GSE24585Up0.4612021436
GSE37065Down-0.0800875443
GSE28863_A1Down-0.2471819467
GSE28863_A2Down-0.0475348894
GSE28863_A3Down-0.0592728286
GSE28863_A4Up0.1865238746
GSE48662Down-0.3564250966

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT018193MicroarrayFunctional MTI (Weak)18185580
hsa-let-7b-5pMIMAT0000063MIRT032319ProteomicsFunctional MTI (Weak)18668040
hsa-miR-877-3pMIMAT0004950MIRT036977CLASHFunctional MTI (Weak)23622248
hsa-miR-423-5pMIMAT0004748MIRT038082CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25412306We identified 107 proteins that could be potential markers of senescence and validated 10 of them (DEP1, NTAL, EBP50, STX4, VAMP3, ARMX3, B2MG, LANCL1, VPS26A and PLD3)
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