HCSGD entry for TCEAL1
1. General information
| Official gene symbol | TCEAL1 |
|---|---|
| Entrez ID | 9338 |
| Gene full name | transcription elongation factor A (SII)-like 1 |
| Other gene symbols | SIIR p21 pp21 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | NAS | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7241195661 | 0.3207833023 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0571039085 |
| GSE13712_SHEAR | Down | -0.2973624692 |
| GSE13712_STATIC | Down | -0.1020209713 |
| GSE19018 | Down | -0.0110526593 |
| GSE19899_A1 | Down | -0.2819547392 |
| GSE19899_A2 | Down | -0.1581844635 |
| PubMed_21979375_A1 | Down | -0.8365619462 |
| PubMed_21979375_A2 | Down | -0.1751878053 |
| GSE35957 | Up | 0.4447761619 |
| GSE36640 | Up | 0.7474254108 |
| GSE54402 | Down | -0.0050261995 |
| GSE9593 | Up | 0.1782867122 |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Down | -0.5123214476 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-22-3p | MIMAT0000077 | MIRT006444 | Immunoblot//Luciferase reporter assay//qRT-PCR | Functional MTI | 21565979 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT005789 | Western blot | Functional MTI | 21226887 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT005792 | Western blot | Functional MTI | 21226887 |
| hsa-miR-106b-5p | MIMAT0000680 | MIRT005847 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 21283757 |
| hsa-miR-106b-5p | MIMAT0000680 | MIRT005847 | Luciferase reporter assay | Functional MTI | 22613985 |
| hsa-miR-106b-5p | MIMAT0000680 | MIRT005847 | Microarray | Functional MTI (Weak) | 17242205 |
| hsa-miR-663a | MIMAT0003326 | MIRT006732 | Luciferase reporter assay | Functional MTI | 22249270 |
| hsa-miR-605-5p | MIMAT0003273 | MIRT016156 | qRT-PCR | Functional MTI (Weak) | 21217645 |
| hsa-miR-504-5p | MIMAT0002875 | MIRT016255 | Western blot;qRT-PCR | Non-Functional MTI | 20542001 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029229 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24484372 | We found not only marked attenuation of E- and A-type cyclins, but also increased expression of p16 and p-p21 |
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