HCSGD entry for ACVR2B

1. General information

Official gene symbolACVR2B
Entrez ID93
Gene full nameactivin A receptor, type IIB
Other gene symbolsACTRIIB ActR-IIB HTX4
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001702Gastrulation with mouth forming secondIEAbiological_process
GO:0001822Kidney developmentIEAbiological_process
GO:0001946LymphangiogenesisISSbiological_process
GO:0001974Blood vessel remodelingISSbiological_process
GO:0004674Protein serine/threonine kinase activityEXP IMPmolecular_function
GO:0004702Receptor signaling protein serine/threonine kinase activityIEAmolecular_function
GO:0004712Protein serine/threonine/tyrosine kinase activityIEAmolecular_function
GO:0005024Transforming growth factor beta-activated receptor activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0006355Regulation of transcription, DNA-templatedIDAbiological_process
GO:0007165Signal transductionIDAbiological_process
GO:0007178Transmembrane receptor protein serine/threonine kinase signaling pathwayTASbiological_process
GO:0007368Determination of left/right symmetryIEAbiological_process
GO:0007498Mesoderm developmentIEAbiological_process
GO:0007507Heart developmentIEAbiological_process
GO:0009749Response to glucoseIEAbiological_process
GO:0009791Post-embryonic developmentIEAbiological_process
GO:0009952Anterior/posterior pattern specificationIMPbiological_process
GO:0016362Activin receptor activity, type IITASmolecular_function
GO:0019838Growth factor bindingIPImolecular_function
GO:0030073Insulin secretionIEAbiological_process
GO:0030324Lung developmentIEAbiological_process
GO:0030501Positive regulation of bone mineralizationIMPbiological_process
GO:0030509BMP signaling pathwayIDA IMP TASbiological_process
GO:0031016Pancreas developmentIEAbiological_process
GO:0032147Activation of protein kinase activityIEAbiological_process
GO:0032924Activin receptor signaling pathwayTASbiological_process
GO:0032927Positive regulation of activin receptor signaling pathwayIDAbiological_process
GO:0034711Inhibin bindingIEAmolecular_function
GO:0035265Organ growthIEAbiological_process
GO:0042475Odontogenesis of dentin-containing toothIEAbiological_process
GO:0045669Positive regulation of osteoblast differentiationIMPbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0048185Activin bindingIEAmolecular_function
GO:0048617Embryonic foregut morphogenesisIEAbiological_process
GO:0048705Skeletal system morphogenesisIEAbiological_process
GO:0060021Palate developmentIEAbiological_process
GO:0060836Lymphatic endothelial cell differentiationISSbiological_process
GO:0060840Artery developmentISSbiological_process
GO:0060841Venous blood vessel developmentISSbiological_process
GO:0061298Retina vasculature development in camera-type eyeISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.31690657650.65664374450.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1219368199
GSE13712_SHEARDown-0.1598485675
GSE13712_STATICDown-0.2795337417
GSE19018Up0.2184245419
GSE19899_A1Up0.0486272030
GSE19899_A2Down-0.0603858358
PubMed_21979375_A1Up0.5108164620
PubMed_21979375_A2Down-0.0645517098
GSE35957Down-0.1102739613
GSE36640Down-0.2113835229
GSE54402Up0.5477549197
GSE9593Up0.0269356314
GSE43922Up0.0144866860
GSE24585Up0.0867357897
GSE37065Down-0.0645987937
GSE28863_A1Up0.7826057336
GSE28863_A2Up0.7001984443
GSE28863_A3Down-0.0152414858
GSE28863_A4Down-0.1241504905
GSE48662Down-0.2241744529

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-200c-3pMIMAT0000617MIRT006343Luciferase reporter assay//Western blotFunctional MTI22431721
hsa-miR-141-3pMIMAT0000432MIRT006342Luciferase reporter assay//Western blotFunctional MTI22431721
hsa-miR-194-5pMIMAT0000460MIRT006341Luciferase reporter assay//Western blotFunctional MTI22431721
hsa-miR-215-5pMIMAT0000272MIRT006340Luciferase reporter assay//Western blotFunctional MTI22431721
hsa-miR-192-5pMIMAT0000222MIRT006339Luciferase reporter assay//Western blotFunctional MTI22431721
hsa-miR-192-5pMIMAT0000222MIRT006339MicroarrayFunctional MTI (Weak)19074876
hsa-miR-335-5pMIMAT0000765MIRT018170MicroarrayFunctional MTI (Weak)18185580
hsa-miR-140-3pMIMAT0004597MIRT021666SequencingFunctional MTI (Weak)20371350
hsa-miR-103a-3pMIMAT0000101MIRT027103SequencingFunctional MTI (Weak)20371350
hsa-miR-101-3pMIMAT0000099MIRT027313SequencingFunctional MTI (Weak)20371350
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

19193721Mutation of BMPRII receptor, but not TGFbetaRII, ACTRIIA, or ACTRIIB, blocked BMP7-induced repression of the hTERT gene promoter activity, leading to increased telomerase activity, lengthened telomeres, and continued cell proliferation
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