HCSGD entry for S1PR2
1. General information
| Official gene symbol | S1PR2 |
|---|---|
| Entrez ID | 9294 |
| Gene full name | sphingosine-1-phosphate receptor 2 |
| Other gene symbols | AGR16 EDG-5 EDG5 Gpcr13 H218 LPB2 S1P2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000187 | Activation of MAPK activity | TAS | biological_process |
| GO:0004930 | G-protein coupled receptor activity | TAS | molecular_function |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0007186 | G-protein coupled receptor signaling pathway | TAS | biological_process |
| GO:0008284 | Positive regulation of cell proliferation | TAS | biological_process |
| GO:0008289 | Lipid binding | TAS | molecular_function |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0038036 | Sphingosine-1-phosphate receptor activity | IEA | molecular_function |
| GO:0090394 | Negative regulation of excitatory postsynaptic membrane potential | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9607862619 | 0.1884463090 | 0.9999902473 | 0.8412644674 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0650074079 |
| GSE13712_SHEAR | Up | 0.0763521521 |
| GSE13712_STATIC | Down | -0.0761927553 |
| GSE19018 | Down | -0.6025049211 |
| GSE19899_A1 | Down | -0.2355077069 |
| GSE19899_A2 | Down | -0.1795824891 |
| PubMed_21979375_A1 | Down | -0.2862211990 |
| PubMed_21979375_A2 | Up | 0.0866143205 |
| GSE35957 | Down | -0.0741291360 |
| GSE36640 | Down | -0.0575477505 |
| GSE54402 | Up | 0.0750938140 |
| GSE9593 | Up | 0.0285302485 |
| GSE43922 | Up | 0.0185979671 |
| GSE24585 | Down | -0.0302064065 |
| GSE37065 | Down | -0.1720022541 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Down | -0.0441915867 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 18765664 | Increased expression of S1P(1) and S1P(2) was also observed in the lesion regions of atherosclerotic endothelium, where senescent ECs have been identified in vivo |
| 18765664 | Rac activation and senescent-associated impairments were restored in senescent ECs by the expression of dominant-negative PTEN and by knocking down S1P(2) receptors |
| 18765664 | Furthermore, the senescent-associated impairments were induced in young ECs by the expression of S1P(2) to a level similar to that of in vitro senescence |
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